Muir-Torre syndrome patients have multiple visceral malignancies along with cutaneous sebaceous tumors and keratoacanthomas. We describe a history of a 64-year-old male patient with 13 tumours, who survived 13 years. The initial ascending colon adenocarcinoma was followed by some different tumors of the skin: adenoma and carcinoma of sebaceous glands, epidermoid and basaloid carcinoma and other benign tumors. The last time developed rectal adenocarcinoma was operated.
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Arch Dermatol Res
January 2025
Department of Dermatology, Columbia University Irving Medical Center, 161 Ft Washington Ave, 12th Floor, New York, NY, 10032, USA.
Sebaceous carcinoma is a rare cutaneous malignancy of sebaceous glands, but it is up to 25-fold more common in immunosuppressed individuals. In this narrative review, we examine the current literature on the pathogenesis, incidence, risk factors, prognosis, treatment, and surveillance of sebaceous carcinoma in immunosuppression and highlight practical considerations for providers who care for these patients. Increased incidence may be related to decreased immune surveillance, susceptibility to an unknown viral trigger, microsatellite instability, immunosuppressive medications, and unmasking of occult Muir-Torre Syndrome.
View Article and Find Full Text PDFJ Am Acad Dermatol
December 2024
Department of Dermatology, Baylor College of Medicine, Houston, Texas.
Sebaceous gland hyperplasia is a benign cutaneous entity commonly seen in older men. Occasionally, it can develop in young patients on immunosuppression with cyclosporine or in adolescent boys in the peripubertal age group. It is extremely rare in young children with no reports of eyelid involvement.
View Article and Find Full Text PDFCancer Genet
November 2024
Eastern Virginia Medical School, Norfolk, VA, USA; Virginia Oncology Associates, Norfolk, VA, USA.
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