Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1103/PhysRevLett.77.2806 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Superparamagnetic nanoparticles as potential systems for the treatment of Duchenne muscular dystrophy.
Nanoscale
January 2025
Department of Chemistry, Federal University of São Paulo (UNIFESP), Diadema, SP, Brazil.
This study aims to use superparamagnetic iron oxide nanoparticles (SPIONs), specifically magnetite (FeO), to deliver deflazacort (DFZ) and ibuprofen (IBU) to Duchenne muscular dystrophy-affected (DMD) mouse muscles using an external magnetic field. The SPIONs are synthesized by the co-precipitation method, and their surfaces are functionalized with L-cysteine to anchor the drugs, considering that the cysteine on the surface of the SPIONs in the solid state dimerizes to form the cystine molecule, creating the FeO-(Cys)-DFZ and FeO-(Cys)-IBU systems for tests. The FeO nanoparticles (NPs) were characterized by Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, powder X-ray diffraction (PXRD), transmission electron microscopy (TEM), dynamic light scattering (DLS), and magnetic measurements.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.
Background: Current evidence suggests that hippocampal subfields have partially different genetic architecture and may improve the sensitivity of the detection of Alzheimer's disease (AD). In this study, we investigated whether genetic predisposition to AD contributes to the accelerated rate of hippocampal volume atrophy across sex and AD stages and how this contribution is specifically driven by functional variants located in the APOE gene.
Methods: The study comprised 1,051 participants from ADNI cohort (75.
Phase Control in Monometallic and Alloy Nanomaterials.
Chem Rev
January 2025
Division of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan.
Metal nanomaterials with unconventional phases have been recently developed with a variety of methods and exhibit novel and attractive properties such as high activities for various catalytic reactions and magnetic properties. In this review, we discuss the progress and the trends in strategies for synthesis, crystal structure, and properties of phase-controlled metal nanomaterials in terms of elements and the combination of alloys. We begin with a brief introduction of the anomalous phase behavior derived from the nanosize effect and general crystal structures observed in metal nanomaterials.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Weill Cornell Medicine, New York, NY, USA.
Background: Different subtypes of Alzheimer's Disease (AD) are shown to have differential patterns of tau deposition on the cerebral cortex. However, for cognitively unimpaired elders the spatial specificity of tau deposition has not been fully investigated.
Objective: We aim to show that tau deposition in different brain regions is uniquely associated with performance in different cognitive domains.
Background: Alzheimer's Disease (AD) is characterized by progressive impairment of cognition and memory, including the loss of episodic memory. The use of non-invasive brain stimulation therapies to modulate memory encoding processes is a promising avenue for potential treatment. Previous studies have shown that the use of Transcranial Magnetic Stimulation (TMS) applied to lateral parietal cortex can improve memory in older adults who have received a diagnosis of Mild Cognitive Impairment.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!