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http://dx.doi.org/10.1103/PhysRevLett.77.28 | DOI Listing |
Microorganisms
January 2025
Translational Neuropharmacology Laboratory, Department of Psychology, University of Cyprus, 75 Kallipoleos Avenue, 1678 Nicosia, Cyprus.
For decades, Alzheimer's Disease (AD) research has focused on the amyloid cascade hypothesis, which identifies amyloid-beta (Aβ) as the primary driver of the disease. However, the consistent failure of Aβ-targeted therapies to demonstrate efficacy, coupled with significant safety concerns, underscores the need to rethink our approach to AD treatment. Emerging evidence points to microbial infections as environmental factors in AD pathoetiology.
View Article and Find Full Text PDFCancers (Basel)
January 2025
Department of Neurology, University Hospital Nürnberg, Paracelsus Medical University, 90471 Nürnberg, Germany.
Breast cancer patients who develop brain metastases have a high mortality rate and a massive decrease in quality of life. Approximately 10-15% of all patients with breast cancer (BC) and 5-40% of all patients with metastatic BC develop brain metastasis (BM) during the course of the disease. However, there is only limited knowledge about prognostic factors in the treatment of patients with brain metastases in breast cancer (BMBC).
View Article and Find Full Text PDFNat Biotechnol
January 2025
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.
Extending single-cell analysis to intact tissues while maintaining organ-scale spatial information poses a major challenge due to unequal chemical processing of densely packed cells. Here we introduce Continuous Redispersion of Volumetric Equilibrium (CuRVE) in nanoporous matrices, a framework to address this challenge. CuRVE ensures uniform processing of all cells in organ-scale tissues by perpetually maintaining dynamic equilibrium of the tissue's gradually shifting chemical environment.
View Article and Find Full Text PDFJ Shoulder Elbow Surg
January 2025
Department of Orthopaedics and Rehabilitation, Penn State Health, Milton S. Hershey Medical Center, Hershey, PA, USA.
Background: There is a paucity of literature discussing anticoagulation prescribing patterns after upper extremity orthopedic surgery. The purpose of this study is to use a large national database to identify trends in adverse events and anticoagulation prescribing following orthopedic shoulder surgery.
Materials And Methods: The TriNetX Research Network was utilized to identify all patients undergoing orthopedic shoulder surgery between January 2004 and December 2022.
Entropy (Basel)
January 2025
Quantum ICT Research Institute, Tamagawa University, Tokyo 194-8610, Japan.
The limitations of cloning and discriminating quantum states are related to the non-orthogonality of the states. Hence, understanding the collective features of quantum states is essential for the future development of quantum communications technology. This paper investigates the non-orthogonality of different coherent-state signal constellations used in quantum communications, namely phase-shift keying (PSK), quadrature-amplitude modulation (QAM), and a newly defined signal named the sunflower-like (SUN) coherent-state signal.
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