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Integrated single-cell RNA sequencing reveals the tumor heterogeneity and microenvironment landscape during liver metastasis in adenocarcinoma of esophagogastric junction.
Front Immunol
January 2025
Department of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Background: Adenocarcinoma of the esophagogastric junction (AEGJ) is a highly aggressive tumor that frequently metastasizes to the liver. Understanding the cellular and molecular mechanisms that drive this process is essential for developing effective therapies.
Methods: We employed single-cell RNA sequencing to analyze the tumor heterogeneity and microenvironmental landscape in patients with AEGJ liver metastases.
Connections Across Open Water: A Bi-Organelle, Genomics-Scale Assessment of Atlantic-Wide Population Dynamics in a Pelagic, Endangered Apex Predator Shark ().
Evol Appl
January 2025
Save Our Seas Foundation Shark Research Center, Halmos College of Arts & Sciences Nova Southeastern University Dania Florida USA.
Large-bodied pelagic sharks are key regulators of oceanic ecosystem stability, but highly impacted by severe overfishing. One such species, the shortfin mako shark (), a globally widespread, highly migratory predator, has undergone dramatic population reductions and is now Endangered (IUCN Red List), with Atlantic Ocean mako sharks in particular assessed by fishery managers as overfished and in need of urgent, improved management attention. Genomic-scale population assessments for this apex predator species have not been previously available to inform management planning; thus, we investigated the population genetics of mako sharks across the Atlantic using a bi-organelle genomics approach.
View Article and Find Full Text PDFComputer-assisted discovery of natural inhibitors for platelet-derived growth factor alpha as novel therapeutics for thyroid cancer.
Front Pharmacol
January 2025
Department of Biochemistry, Bahauddin Zakariya University, Multan, Pakistan.
Platelet-derived growth factor alpha (PDGFRA) plays a significant role in various malignant tumors. PDGFRA expression boosts thyroid cancer cell proliferation and metastasis. Radiorefractory thyroid cancer is poorly differentiated, very aggressive, and resistant to radioiodine therapy.
View Article and Find Full Text PDFPreparation and characterization of edible films from gelatin and hydroxypropyl methyl cellulose/sodium carboxymethyl cellulose.
Heliyon
January 2025
Institute of Agro-products Processing, Anhui Academy of Agricultural Sciences, Hefei, Anhui, 230041, China.
This study investigates the enhancement of gelatin (GEL) films using hydroxypropyl methylcellulose (HPMC) and carboxymethyl cellulose (CMC) for edible film packaging applications. Although GEL is biocompatible and cost-effective, its limited mechanical strength presents significant challenges for practical applications. The findings indicate that CMC effectively increases tensile strength (TS), while HPMC improves elongation at break (EAB) and hydrophilicity.
View Article and Find Full Text PDFDynamic surface behavouir and aqueous foam properties of graphene- polystyrene sulfonate / Cetyl trimethylammonium bromide mixtures.
Heliyon
January 2025
Department of Chemical Engineering, Quchan Branch, Islamic Azad University, Quchan, Iran.
An interface can be delicately designed using interactions between nanoparticles and surfactants by controlling surface properties such as activity and charge equilibrium. This study seeks to provide insights into how surfactant concentration impacts the stability and dynamics of nanoparticle-surfactant interfaces, with potential applications in material science and interface engineering. This study investigates the interactions between Graphene Function (Gr, Graphene function in this text refers to functionalizing the graphene sheets with -COOH groups via acidic reactions.
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