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A whole gamma imaging prototype for higher quantitative imaging ofZr-labeled antibodies in a tumor mouse model.
Phys Med Biol
January 2025
National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, JAPAN.
PET has become an important clinical modality but is limited to imaging positron emitters. Recently, PET imaging withZr, which has a half-life of 3 days, has attracted much attention in immuno-PET to visualize immune cells and cancer cells by targeting specific antibodies on the cell surface. However,Zr emits a single gamma ray at 909 keV four times more frequently than positrons, causing image quality degradation in conventional PET.
View Article and Find Full Text PDFDemonstration of active neutron interrogation of special nuclear materials using a high-intensity short-pulse-laser-driven neutron source.
Sci Rep
January 2025
Los Alamos National Laboratory, Los Alamos, NM, 87544, USA.
Detecting shielded special nuclear material, such as nuclear explosives, is a difficult challenge pursued by non-proliferation, anti-terrorism, and nuclear security programs worldwide. Interrogation with intense fast-neutron pulses is a promising method to characterize concealed nuclear material rapidly but is limited by suitable source availability and proven instrumentation. In this study we have pioneered a demonstration of such an interrogation method using a high-intensity, short-pulse, laser-driven neutron source that offers potential benefits compared to conventional neutron sources.
View Article and Find Full Text PDFTargeting Fibroblast Activation Protein for Molecular Imaging of Fibrotic Remodeling in Pulmonary Arterial Hypertension.
J Nucl Med
January 2025
Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou, China; and
The purpose of this study was to investigate the feasibility of using F-labeled fibroblast activation protein inhibitor (FAPI) PET/CT in assessing the fibrotic remodeling of the pulmonary artery (PA) and the right ventricle (RV) in pulmonary arterial hypertension (PAH). In a rat model of monocrotaline-induced PAH, rats were euthanized at different time points for tissue analysis (fibroblast activation protein immunofluorescence and Masson's trichrome staining) after completing F-FAPI PET/CT and hemodynamic measurements. Thirty-eight PAH patients were enrolled to participate in F-FAPI PET/CT imaging, with right heart catheterization and echocardiography performed within 1 wk to assess pulmonary hemodynamics and cardiac function.
View Article and Find Full Text PDFProton- and deuteron-induced cross sections on natural platinum.
Appl Radiat Isot
December 2024
Nuclear & Chemical Sciences Division, Lawrence Livermore National Laboratory, United States.
Light-ion irradiations on natural platinum were performed to measure gold-radioisotope cross sections and isotope ratios, as well as to produce a carrier-free final product. Experimental cross sections are compared to TENDL-2023. There is good agreement with this work's results and other published literature values.
View Article and Find Full Text PDFQuantum Thermodynamics of Nonequilibrium Processes in Lattice Gauge Theories.
Phys Rev Lett
December 2024
Joint Center for Quantum Information and Computer Science, NIST and University of Maryland, College Park, Maryland 20742, USA.
A key objective in nuclear and high-energy physics is to describe nonequilibrium dynamics of matter, e.g., in the early Universe and in particle colliders, starting from the standard model of particle physics.
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