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Changes in muscle performance among older adults with myeloid malignancies engaging in a mobile health (mHealth) exercise intervention: a single arm pilot study.
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January 2025
James P. Wilmot Cancer Institute, Rochester, New York, USA.
Background: Older adults with cancer are vulnerable to declines in muscle performance (e.g., strength, speed, duration of muscular contraction), which are associated with worse cancer-related outcomes.
View Article and Find Full Text PDFEvaluation of the natural suitability of human settlements in the Western Sichuan Plateau region of China.
Sci Rep
January 2025
College of Geography and Planning, Chengdu University of Technology, Chengdu, 610059, China.
The natural suitability of human settlements is greatly influenced by the distinct ecological environment and natural conditions of the plateau area, which are of great eco-environmental significance. 32 counties in China's Western Sichuan Plateau were chosen as the study's research subjects. The evaluation index system and weight of the natural suitability of human settlements were established, along with the obstacle degree model, using the analytical hierarchy process, the entropy method, and the integrated weight method.
View Article and Find Full Text PDFComparing acute versus AIDS ART initiation on HIV-1 integration sites and clonal expansion.
Signal Transduct Target Ther
January 2025
National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518112, Guangdong Province, China.
Early antiretroviral therapy (ART) initiation is known to limit the establishment of the HIV reservoir, with studies suggesting benefits such as a reduced number of infected cells and a smaller latent reservoir. However, the long-term impact of early ART initiation on the dynamics of the infected cell pool remains unclear, and clinical evidence directly comparing proviral integration site counts between early and late ART initiation is limited. In this study, we used Linear Target Amplification-PCR (LTA-PCR) and Next Generation Sequencing to compare unique integration site (UIS) clonal counts between individuals who initiated ART during acute HIV infection stage (Acute-ART group) and those in the AIDS stage (AIDS-ART group).
View Article and Find Full Text PDFAvoidable factors associated with maternal death from postpartum haemorrhage: a national Malawian surveillance study.
BMJ Glob Health
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Women's and Children's Health, University of Liverpool, Liverpool, UK.
Background: Despite strong evidence-based strategies for prevention and management, global efforts to reduce deaths from postpartum haemorrhage (PPH) have failed, and it remains the leading cause of maternal mortality. We conducted a detailed review of all maternal deaths from 33 facilities in Malawi to identify health system weaknesses leading to deaths from PPH.
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Structural and functional characterization of a histidylated liposome for mRNA delivery.
J Control Release
January 2025
Centre de Biophysique Moléculaire, CBM, CNRS UPR4301, Orléans, France. Electronic address:
The development of lipid-based mRNA delivery systems has significantly facilitated recent advances in mRNA-based therapeutics. Liposomes, as the pioneering class of mRNA vectors, continue to lead in clinical trials. We previously developed a histidylated liposome that demonstrated efficient nucleic acid delivery.
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