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Transcriptomic profiling of chronic hand eczema skin reveals shared immune pathways and molecular drivers across subtypes.
J Allergy Clin Immunol
January 2025
The National Allergy Research Centre, Department of Dermatology and Allergy, Copenhagen University Hospital, Herlev-Gentofte, Hellerup, Denmark.
Background: Chronic hand eczema (CHE) is a common skin disease with different subtypes, but knowledge of the molecular patterns associated with each subtype is limited.
Objective: To characterize the CHE transcriptome across subtypes.
Methods: Using RNA-sequencing, we studied the transcriptome of 220 full-thickness skin biopsies collected from palms, dorsa, and arms from 96 patients with CHE and/or atopic dermatitis (AD) and 32 healthy controls.
Integrated bioinformatics analysis and experimental validation of exosome-related gene signature in steroid-induced osteonecrosis of the femoral head.
J Orthop Surg Res
January 2025
Department of Hand-Foot Microsurgery, Shenzhen Nanshan People's Hospital, The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China.
Background: Steroid-induced osteonecrosis of the femoral head (SIONFH) is a universal hip articular disease and is very hard to perceive at an early stage. The understanding of the pathogenesis of SIONFH is still limited, and the identification of efficient diagnostic biomarkers is insufficient. This research aims to recognize and validate the latent exosome-related molecular signature in SIONFH diagnosis by employing bioinformatics to investigate exosome-related mechanisms in SIONFH.
View Article and Find Full Text PDFA universal gene expression signature-based strategy for the high-throughput discovery of anti-inflammatory drugs.
Inflamm Res
January 2025
Medical Systems Biology Research Center, School of Medicine, Tsinghua University, Beijing, 100084, China.
Background: Traditional Chinese medicine (TCM) is a valuable resource for drug discovery and has demonstrated excellent efficacy in treating inflammatory diseases. This study aimed to develop a universal gene signature-based strategy for high-throughput discovery of anti-inflammatory drugs, especially Traditional Chinese medicine (TCM).
Methods: The disease gene signature of liposaccharide-stimulated THP-1 cells and drug gene signatures of 655 drug candidates were established via sequencing.
Immunological memory in a teleost fish: common carp IgM B cells differentiate into memory and plasma cells.
Front Immunol
January 2025
Laboratory of Fish Protistology, Institute of Parasitology, Biology Centre, Czech Academy of Sciences, České Budějovice, Czechia.
Article Synopsis
- All vertebrates, from ancient fishes to mammals, possess adaptive immunity and immunological memory, although the specific responding cells in fish have not been clearly defined.
- Researchers infected common carp with a cnidarian parasite and observed that B cells proliferated and showed signs of differentiation, indicating they can form memory cells.
- The study revealed that these memory B cells can persist for at least six months, alongside identifying a distinct population of plasma cells, suggesting that teleost fish possess the necessary immune components for effective long-term disease protection akin to other vertebrates.
Detecting a Long-Lived False Vacuum with Quantum Quenches.
Phys Rev Lett
December 2024
Center for Theoretical Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Distinguishing whether a system supports alternate low-energy (locally stable) states-stable (true vacuum) versus metastable (false vacuum)-by direct observation can be difficult when the lifetime of the state is very long but otherwise unknown. Here we demonstrate, in a tractable model system, that there are physical phenomena on much shorter timescales that can diagnose the difference. Specifically, we study the time evolution of the magnetization following a quench in the tilted quantum Ising model, and show that its magnitude spectrum is an effective diagnostic.
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