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Brain temperature mapping based on chemical exchange saturation transfer signal at 2 ppm.
Quant Imaging Med Surg
January 2025
Paul. C. Lauterbur Research Centers for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Background: Brain temperature signifies the thermal homeostasis of the tissue, and may serve as a marker for neuroprotective therapy. Currently, it remains challenging to map the human brain temperature with high spatial resolution. The thermal dependence of chemical exchange saturation transfer (CEST) effects of endogenous labile protons may provide a promising mechanism for the absolute brain temperature imaging.
View Article and Find Full Text PDFSynthesis, antifungal activity, and molecular simulation study of nootkatone-based thiazole-hydrazone compounds as novel succinate dehydrogenase inhibitor.
Pest Manag Sci
January 2025
School of Chemistry and Chemical Engineering, Guangxi University, Nanning, P. R. China.
Background: Plant diseases cause huge losses in agriculture worldwide every year, but the prolonged use of current commercial fungicides has led to the development of resistance in plant pathogenic fungi. Therefore, there is an urgent need to develop new, efficient, and green fungicides.
Results: Twenty-three nootkatone-based thiazole-hydrazone compounds were designed, synthesized, and characterized by Fourier-transform infrared (FTIR), proton (H) nuclear magnetic resonance (NMR), carbon-13 (C) NMR, and high-resolution mass spectrometry (HRMS).
Development of an G Protein-Coupled Receptor Fragment Molecule Screening Approach with High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance.
ACS Chem Biol
January 2025
Department of Chemistry, University of Florida, Gainesville Florida 32611, United States.
Small molecules are essential for investigating the pharmacology of membrane proteins and remain the most common approach for therapeutically targeting them. However, most experimental small molecule screening methods require ligands containing radiolabels or fluorescent labels and often involve isolating proteins from their cellular environment. Additionally, most conventional screening methods are suited for identifying compounds with moderate to higher affinities ( < 1 μM) and are less effective at detecting lower affinity compounds, such as weakly binding molecular fragments.
View Article and Find Full Text PDFGastric Accommodation Testing Using Hybrid Nuclear Imaging Volumetry and Combined High-Resolution Manometry-Nutrient Drink Test: A Pilot Study in Healthy Individuals.
Neurogastroenterol Motil
January 2025
Department of Nuclear Medicine, Radiotherapy & Oncology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kota Bharu, Kelantan, Malaysia.
Background: Gastric accommodation (GA) testing is gaining clinical recognition as novel and minimally invasive modalities emerge. We investigated the feasibility of hybrid nuclear imaging volumetry (SPECT/CT) and combined high-resolution manometry-nutrient drink test (HRM-NDT) to assess GA.
Methods: In this non-randomized pilot study, [Tc]NaTcO gastric SPECT/CT (250 mL protocol) and proximal gastric HRM-NDT (~60 mL/min protocol) were performed separately within 30 days using Ensure Gold test meal (1.
Prediction of early lung adenocarcinoma spread through air spaces by machine learning radiomics: a cross-center cohort study.
Transl Lung Cancer Res
December 2024
Department of Radiology, The Xuzhou Hospital Affiliated to Jiangsu University, Xuzhou, China.
Background: Sublobar resection is suitable for peripheral stage I lung adenocarcinoma (LUAD). However, if tumor spread through air spaces (STAS) present, the lobectomy will be considered for a survival benefit. Therefore, STAS status guide peripheral stage I LUAD surgical approach.
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