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AI integration into wavelength-based SPR biosensing: Advancements in spectroscopic analysis and detection.
Anal Chim Acta
March 2025
Artificial Intelligence Research Center, Chang Gung University, Taoyuan, 333323, Taiwan; Department of Artificial Intelligence, College of Intelligent Computing, Chang Gung University, Taoyuan, 333323, Taiwan. Electronic address:
Background: In recent years, employing deep learning methods in the biosensing area has significantly reduced data analysis time and enhanced data interpretation and prediction accuracy. In some SPR fields, research teams have further enhanced detection capabilities using deep learning techniques. However, the application of deep learning to spectroscopic surface plasmon resonance (SPR) biosensors has not been reported.
View Article and Find Full Text PDFScientific-grade spectrometers with high hyperspectral resolution and high spectral accuracy are desirable in miniaturized optical systems to maintain stable and real-time spectral sampling. Fourier transform spectrometers that utilize high-precision moving mirrors generally struggle to enhance their miniaturization and stable real-time performance. A static infrared spectral measurement method is proposed that uses micro/nano-optical devices as the core of static interference and lightweight imaging.
View Article and Find Full Text PDFMultilevel diffractive lenses with a small -number (#≤10) and a high diffraction efficiency can shorten optical system length and improve system detection accuracy. The diffraction efficiency of the multilevel diffractive lens fabricated by the high-precision, low-cost nanofabrication method proposed in this paper reaches 90% of the maximum theoretical diffraction efficiency. Furthermore, the spectral imaging characteristics of the diffractive lens are theoretical analysis and experimental verification.
View Article and Find Full Text PDFChirp modulation can generate a relatively flat electro-optic frequency comb (EO comb) and offers the advantage of frequency reconfigurability, demonstrating significant potential in high-precision sensing and absorption spectroscopy measurements. However, nonresonant devices such as waveguides are susceptible to limitations in modulation efficiency and bandwidth during electro-optic modulation. In this paper, by utilizing chirp modulation resonance mode, we have realized an EO comb based on a lithium niobate resonator with small tooth spacing and high flatness.
View Article and Find Full Text PDFA high-sensitivity hot-wire anemometer is proposed for use with a cobalt-doped fiber (CDF) based long-period grating (LPG) heated optically by a 1480 nm laser. The CDF-LPG absorbs laser power and generates heat inherently, thereby eliminating the need for both metal coating and mode coupling devices that are usually required in optical fiber grating anemometers. The dip wavelength of the CDF-LPG shifts with airflow velocity due to the cooling effect of the airflow.
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