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Danshensu enhances autophagy and reduces inflammation by downregulating TNF-α to inhibit the NF-κB signaling pathway in ischemic flaps.
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Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China,; Zhejiang Provincial Key Laboratory of Orthopaedics, Wenzhou 325027, China, ; The Second Clinical Medical College of Wenzhou Medical University, Wenzhou 325027, China. Electronic address:
Background: The significant distal necrosis of the random-pattern skin flaps greatly restricts their clinical applications in flap transplantation. Previous studies have demonstrated the potential of danshensu (DSS) to alleviate ischemic tissue injury. However, no research to date has confirmed whether DSS can improve the survival of ischemic flaps.
View Article and Find Full Text PDFFramework Nucleic Acid-Based and Neutrophil-Based Nanoplatform Loading Baicalin with Targeted Drug Delivery for Anti-Inflammation Treatment.
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State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
Targeted drug delivery is a promising strategy for treating inflammatory diseases, with recent research focusing on the combination of neutrophils and nanomaterials. In this study, a targeted nanodrug delivery platform (Ac-PGP-tFNA, APT) was developed using tetrahedral framework nucleic acid (tFNA) along with a neutrophil hitchhiking mechanism to achieve precise delivery and anti-inflammatory effects. The tFNA structure, known for its excellent drug-loading capacity and cellular uptake efficiency, was used to carry a therapeutic agent─baicalin.
View Article and Find Full Text PDFAdaptation of clinical bacteriology techniques for remote polar research.
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Clinical Infection Department, Chelsea and Westminster Hospital NHS Foundation Trust, London, United Kingdom.
Unlabelled: Remote polar regions offer unique opportunities and significant challenges for antimicrobial resistance research in a near-pristine environment. While core microbiology techniques continue to have an important role in supporting environmental research, the severe cold climate presents considerable challenges to laboratory research. We explore adaptations required for core bacteriology investigations in polar regions on an unsupported remote expedition c.
View Article and Find Full Text PDFRole of macrophage polarization in diabetic foot ulcer healing: A bibliometric study.
World J Diabetes
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View Article and Find Full Text PDFFinding polarized communities and tracking information diffusion on Twitter: a network approach on the Irish Abortion Referendum.
R Soc Open Sci
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Mathematics Application Consortium for Science and Industry (MACSI), University of Limerick, Limerick, Ireland.
The analysis of social networks enables the understanding of social interactions, polarization of ideas and the spread of information, and therefore plays an important role in society. We use Twitter data-as it is a popular venue for the expression of opinion and dissemination of information-to identify opposing sides of a debate and, importantly, to observe how information spreads between these groups in our current polarized climate. To achieve this, we collected over 688 000 tweets from the Irish Abortion Referendum of 2018 to build a conversation network from users' mentions with sentiment-based homophily.
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