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Lateralization of the Aberrant Amplitude of Low-Frequency Fluctuation within the Default Mode Network in Patients with Mild Cognitive Impairment.
Acad Radiol
January 2025
Department of Radiology, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai 200031, China (Q.X.). Electronic address:
Rationale And Objectives: Alzheimer's disease (AD) is the most common pathogenesis of dementia, and mild cognitive impairment (MCI) is considered as the intermediate stage from normal elderly to AD. Early detection of MCI is an essential step for the timely intervention of AD to slow the progression of this disease. Different form previous studies in the whole-brain spontaneous activities, this research aimed to explore the low-frequency amplitude spectrum activities of patients with MCI within the default mode network (DMN), which has been involved in the process of maintaining normal cognitive function.
View Article and Find Full Text PDFAbnormally slow dynamics in occipital cortex of depression.
J Affect Disord
January 2025
University of Ottawa Institute of Mental Health Research, University of Ottawa, Ottawa, Canada. Electronic address:
Aim: Major depressive disorder (MDD) is characterized by altered activity in various higher-order regions like the anterior cingulate and prefrontal cortex. While some findings also show changes in lower-order sensory regions like the occipital cortex in MDD, the latter's exact neural and temporal, e.g.
View Article and Find Full Text PDFLauryl-NrTP6 lipopeptide self-assembled nanorods for nuclear-targeted delivery of doxorubicin.
Nanoscale
January 2025
Soft Matter Nanotechnology, Center for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Paseo de Miramon 194, 20014, Donostia-San Sebastián, Spain.
Targeted delivery offers solutions for more efficient therapies with fewer side effects. Here, lipopeptides (LPs) prepared by conjugation of the nuclear-targeting peptide analogue H-YKQSHKKGGKKGSG-NH (NrTP6) and two lauric acid chains are used to encapsulate the chemotherapeutic agent doxorubicin (DX) through a solvent-exchange protocol. LPs spontaneously form nanosized rod-like assemblies in phosphate buffer.
View Article and Find Full Text PDFTwo-Step Reshaping of Acicular Gold Nanoparticles.
Nano Lett
January 2025
Institut Charles Sadron, Université de Strasbourg and CNRS, 67034 Strasbourg, France.
Anisometric plasmonic nanoparticles find applications in various fields, from photocatalysis to biosensing. However, exposure to heat or to specific chemical environments can induce their reshaping, leading to loss of function. Understanding this process is therefore relevant both for the fundamental understanding of such nano-objects and for their practical applications.
View Article and Find Full Text PDFThermally Controlled -site Cation Ordering and Coupled Polarity in Double Perovskite NaLaZrO.
Inorg Chem
January 2025
Department of Applied Chemistry, Faculty of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.
-site cation ordering in double perovskites is crucially important for their physical properties. In this study, polycrystalline samples of Zr-based double perovskite NaLaZrO were synthesized via high-temperature solid-state reactions, and the influence of the heating temperature and cooling rate on their crystal structures was investigated using synchrotron X-ray diffractometry and optical second harmonic generation. The samples prepared at 1200 °C, followed by slow cooling to room temperature, crystallize in a polar 2 structure, exhibiting partial -site cation ordering, with Na- and La-rich -site layers alternately stacked along the axis.
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