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Pharmacodynamic activity (leukopoietic effect) of recombinant human granulocyte colony-stimulating factor (rhG-CSF) after rectal administration in rabbits with leukopenia induced by cyclophosphamide.
Biol Pharm Bull
August 1996
Department of Pharmaceutics, Showa College of Pharmaceutical Sciences, Tokyo, Japan.
The pharmacodynamic activity (leukopoietic effect) and pharmacokinetics of recombinant human granulocyte colony-stimulating factor (rhG-CSF) administered in various doses as hollow-type suppositories were investigated in rabbits with leukopenia induced by cyclophosphamide (CPA-treated rabbits). We found that serum granulocyte colony-stimulating factor (G-CSF) concentration was increased following the rectal administration of rhG-CSF. Therefore, rhG-CSF could be absorbed from the rectal mucosa in leukopenic rabbits who received CPA at a dose of 30 mg/kg/d.
View Article and Find Full Text PDFPharmacodynamics and pharmacokinetics of recombinant human granulocyte colony-stimulating factor (rhG-CSF) after administration of a rectal dosage vehicle.
Biol Pharm Bull
August 1996
Department of Pharmaceutics, Showa College of Pharmaceutical Sciences, Tokyo, Japan.
The pharmacodynamic activities (leukopoietic effect) and pharmacokinetics of recombinant human granulocyte colony-stimulating factor (rhG-CSF) administered rectally in various doses as hollow-type suppositories were investigated in rabbits. Three kinds of rhG-CSF hollow-type suppositories were employed: suppository I containing rhG-CSF (100-1000 micrograms/kg) in 10 mM acetate buffer solution (ABS) at pH 4.0, suppository II containing rhG-CSF in ABS with alpha-cyclodextrin (alpha-CyD) as an absorption-enhancing agent, and suppository III containing lyophilized rhG-CSF powder.
View Article and Find Full Text PDF[Experimental study of the early stages of the development of an immune response].
Zh Mikrobiol Epidemiol Immunobiol
January 1983
Experiments in white mice have demonstrated an increase in the levels of damaged leukocytes in the body and in leukopoietic activity of the blood serum after primary immunization. An increase in the content of leukocyte decomposition products in the body, induced by the injection of neutrophil lysate, stimulated antibody formation in mice and enhanced phagocytic and cytotoxic activity of the peritoneal exudate macrophages in rats.
View Article and Find Full Text PDF[Mechanism of action of granulocyte breakdown products on granulocytopoiesis].
Biull Eksp Biol Med
June 1978
Blood serum leukopoietic activity after the injection to intact Wistar rats of products of 12 and 60 million homologous granulocytes lysis per 100 g of animal body weight, and the character of the serum action on the proliferation and differentiation of stem hematopoietic cells in the spleen of lethally irradiated mice were studied. Accumulation in the blood of granulocytopoietins resulting from the action of the products of granulocytes lysis was noted. Granulocytopoietins stimulated the proliferating activity of stem cells and their differentiation into granulocytes in the spleen of the lethally irradiated mice.
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