"Esculap" is a newly developed hospital complex separated into a number of modules, some of which are unique since they were designed and equipped with a view of specialist and emergency medical care provision in the field on the basis of advanced technologies of hemodialysis, hemosorption and plasmapheresis. Its mobility, comfort and up-to-date equipment will improve the medical treatment results, reduce lethality and invalidity rates.
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Eur Heart J
November 2024
Paediatric Cardiac Surgery, San Donato Milanese Hospital, 20097 San Donato Milanese (MI), Italy.
Drugs R D
June 2024
Relmada Therapeutics, Coral Gables, FL, 33134, USA.
Background And Objectives: Esmethadone (dextromethadone; d-methadone; S-methadone (+)-methadone; REL-1017) is a low potency N-methyl--aspartate (NMDA) receptor channel blocker that showed a rapid and sustained adjunctive antidepressant effects in patients with major depressive disorder with inadequate response to ongoing serotonergic antidepressant treatment. Previous studies indicated that esmethadone is partially excreted by the kidney (53.9% of the dose) and by the liver (39.
View Article and Find Full Text PDFInterdiscip Cardiovasc Thorac Surg
March 2024
Medical Skill and Innovation Center, Medical School, University of Pécs, Pécs, Hungary.
Drugs R D
March 2024
Relmada Therapeutics, Coral Gables, FL, 33134, USA.
Background And Objective: Esmethadone (dextromethadone; d-methadone; S-methadone (+)-methadone; REL-1017) is the opioid inactive dextro-isomer of racemic methadone. Esmethadone is a low potency N-methyl-D-aspartate (NMDA) receptor channel blocker with higher affinity for GluN2D subtypes. Esmethadone showed robust, rapid, and sustained antidepressant effects in patients with major depressive disorder (MDD) with inadequate response to ongoing serotonergic antidepressant treatment.
View Article and Find Full Text PDFEnviron Toxicol Pharmacol
June 2023
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences of the University of Messina, Messina, Italy. Electronic address:
The plastic accumulation and its degradation into microplastics is an environmental issue not only for their ubiquity, but also for the release of intrinsic chemicals, such as phthalates (PAEs), non-phthalate plasticizers (NPPs), and bisphenols (BPs), which may reach body organs and tissues, and act as endocrine disruptors. Monitoring plastic additives in biological matrices, such as blood, may help in deriving relationships between human exposure and health outcomes. In this work, the profile of PAEs, NPPs and BPs was determined in Sicilian women's blood with different ages (20-60 years) and interpreted by chemometrics.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!