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Wandering spleen with torsion causing an acute abdomen: A case report.
Int J Surg Case Rep
November 2024
Department of Pathology, Hawassa University Comprehensive Specialized Hospital, Hawassa, Sidama, Ethiopia. Electronic address:
Introduction And Importance: Wandering spleen, also known as ectopic spleen, is an uncommon disorder in which the spleen's anatomical location differs from its fixed position in the abdomen's left upper quadrant. The etiology is either congenital or acquired, possibly leading to torsion and splenic infarction. It affects children and young adults, especially childbearing-age women.
View Article and Find Full Text PDFToxicokinetics and Tissue Distribution of the Hepatotoxic Triterpenoid Saponin Pterocephin A in Rats Using the Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS) Method.
Molecules
October 2024
Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine, Integrative Science, Center of Germplasm Creation in Western China (Chongqing) Science City & Southwest University, SWU-TAAHC Medicinal Plant Joint R&D Centre, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
Pterocephin A is a natural triterpenoid saponin isolated from , a traditional Tibetan medicine with slight toxicity, which can induce liver injury in rats. This study aimed to establish a sensitive and reliable UPLC-MS/MS method for exploring the toxicokinetics and tissue distribution of pterocephin A following single intravenous and intragastric administration. Pterocephin A and prosapogenin 1C (internal standard, IS) were extracted using a simple protein precipitation technique with methanol as the precipitant for plasma samples and methanol/acetonitrile = 1:1 (/) for tissue samples.
View Article and Find Full Text PDFCompact Arterial Monitoring Device Use in Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA): A Simple Validation Study in Swine.
Cureus
October 2024
Department of Anesthesiology, Uniformed Services University of the Health Sciences, Bethesda, USA.
Article Synopsis
- - Hemorrhage is the main cause of preventable death in trauma situations, leading to military and civilian advancements in medical practices, particularly through the use of tourniquets to manage extremity bleeding and save lives.
- - While tourniquets have significantly decreased deaths from bleeding in military settings, noncompressible hemorrhage still poses a major risk, especially before patients receive definitive medical care.
- - The study explores using a small, disposable pressure monitor during resuscitative endovascular balloon occlusion of the aorta (REBOA) to enhance blood pressure monitoring, facilitate better resuscitation practices, and reduce the need for blood products in extreme environments.
Quadruple Negative Metastatic Melanoma With Gain of SOX-11 Expression and TERT Mutation.
Cureus
August 2024
Department of Pathology, University of South Alabama, Mobile, USA.
Article Synopsis
- Malignant melanoma is a serious and common skin cancer that often spreads to other parts of the body, making diagnosis generally straightforward through tissue examination and specialized staining techniques.
- Metastatic melanoma can show many different characteristics and may lose important markers that help identify it, complicating the diagnostic process.
- A case study discusses a 59-year-old man with splenic metastatic melanoma who lost four key markers (S100, SOX-10, HMB45, and MART-1) but gained the marker SOX-11, highlighting the challenges in diagnosing certain melanoma cases.
Newcastle Disease Virus Induces Profound Lymphoid Depletion with Different Patterns of Necroptosis, Necrosis, and Oxidative DNA Damage in Bursa, Spleen, and Other Lymphoid Tissues.
Pathogens
July 2024
School of Animal and Veterinary Sciences, The University of Adelaide, Adelaide, SA 5371, Australia.
This study delves into the pathogenesis of virulent genotype VII strains of the Newcastle disease virus (NDV), focusing on experimentally infected birds. Predominant and consistent lesions observed include bursal atrophy and extensive depletion of all lymphoid tissues. Immunohistochemistry (IHC) analysis, targeting apoptosis (Caspase-3), necroptosis (MLKL), and NDV markers, indicates that bursal atrophy is linked to a non-apoptotic programmed cell death pathway known as "necroptosis".
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