AI Article Synopsis
- A study compared the effects of intravenous midazolam to placebo on persistent postoperative nausea and vomiting (PONV) in patients resistant to standard treatments.
- Patients (ages 18-82) with PONV lasting over six hours were randomly given either midazolam or a placebo.
- Results showed that those receiving midazolam experienced significantly less nausea, vomiting, and required fewer rescue anti-emetics, indicating its effectiveness in reducing persistent PONV.
Article Abstract
The effect of intravenous midazolam on persistent postoperative nausea and vomiting (PONV) was compared to placebo in a prospective randomized double-blind study. Twenty patients aged 18 to 82 years with persistent PONV resistant to standard anti-emetics and present for greater than six hours were randomized to receive either an intravenous infusion of midazolam 1.0 mg/h or placebo. Nausea (P = 0.04), vomiting (P = 0.02) and the use of rescue anti-emetics (P = 0.003) were significantly less in the midazolam group. We conclude that low-dose intravenous infusion of midazolam significantly reduces persistent PONV.
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| http://dx.doi.org/10.1177/0310057X9902700107 | DOI Listing |
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