Some antihypertensive drugs may have a renoprotective effect, that is partially independent of their ability to reduce blood pressure. ACE-inhibitors are safe and effective agents that are capable of reducing proteinuria and preventing CRF progression. The results of the AIPRI extension study suggest that they may also have a long-term renoprotective effect. ACE gene polymorphism may partially influence the response to these agents. Angiotensin II receptor 1 antagonists (AT1RA) are effective in reducing proteinuria, but their clinical impact is still a matter of study. It has been shown that non-dihydropyridine and some dihydropyridine calcium channel blockers (CCBs) reduce proteinuria and are also renoprotective, but there is a lack of large-scale prospective randomised trials. Given that the use of various drugs is usually needed to achieve good blood pressure control in patients with CRF, the possibility that a combination of ACE-inhibitors with CCBs or ATIRAs may have an additive renoprotective effect is intriguing.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Self-monitoring of blood pressure following a stroke or transient ischaemic attack (TASMIN5S): a randomised controlled trial.
BMC Cardiovasc Disord
December 2024
School of Psychology, University of Southampton, Southampton, UK.
Background: Blood pressure (BP) control following stroke is important but currently sub-optimal. This trial aimed to determine whether self-monitoring of hypertension with telemonitoring and a treatment escalation protocol, results in lower BP than usual care in people with previous stroke or transient ischaemic attack (TIA).
Methods: Unblinded randomised controlled trial, comparing a BP telemonitoring-based intervention with control (usual care) for hypertension management in 12 primary care practices in England.
Identification of shared genetic etiology of cardiovascular and cerebrovascular diseases through common cardiometabolic risk factors.
Commun Biol
December 2024
Department of Epidemiology and Biostatistics, School of Public Health, Peking University; Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China.
Cardiovascular diseases (CVDs) and cerebrovascular diseases (CeVDs) are closely related vascular diseases, sharing common cardiometabolic risk factors (RFs). Although pleiotropic genetic variants of these two diseases have been reported, their underlying pathological mechanisms are still unclear. Leveraging GWAS summary data and using genetic correlation, pleiotropic variants identification, and colocalization analyses, we identified 11 colocalized loci for CVDs-CeVDs-BP (blood pressure), CVDs-CeVDs-LIP (lipid traits), and CVDs-CeVDs-cIMT (carotid intima-media thickness) triplets.
View Article and Find Full Text PDFFoliar application of sodium nitroprusside alters the physicochemical properties, antioxidant capacities, and enzymatic activities of strawberry cv. Camarosa.
Sci Rep
December 2024
Horticulture Crops Research Department, West Azerbaijan Agricultural and Natural Resources Research and Education Centre, Agricultural Research, Education and Extension Organization (AREEO), Urmia, Iran.
Strawberry (Fragaria × ananassa) is a horticultural crop known for its sensitivity to mechanical damage and susceptibility to postharvest decay. In recent years, various strategies have been implemented to enhance both the yield and quality of strawberries, among which the application of nitric oxide-producing compounds has garnered special attention. The present study aimed to investigate the effects of varying concentrations of sodium nitroprusside (SNP), specifically 0, 200, 400, and 600 μM, on strawberries (cv.
View Article and Find Full Text PDFInhibition of pterygium cell fibrosis by the Rho kinase inhibitor.
Sci Rep
December 2024
Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, RM305v, 1160 W. Michigan St., Indianapolis, IN, 46202, USA.
Pterygium is an ocular disease in which the conjunctival tissue invades the cornea. When the pterygium tissue reaches the pupillary region, the visual function of the patient is affected. Currently, surgical removal is the only effective treatment.
View Article and Find Full Text PDFAdherence to antihypertensive medications and associated factors in patients with hypertension, Oromia, Ethiopia: a multicenter study.
Sci Rep
December 2024
School of Public Health, Adama Hospital and Medical College, Adama, Ethiopia.
Interventions designed to improve medication adherence, and blood pressure control have not been effective globally. There is limited comprehensive understanding regarding the level of drug adherence to antihypertensive medications in Ethiopia, particularly in the study area. This study aimed to assess adherence to antihypertensive medication and associated factors among patients with hypertension on follow-up at public health facilities of Adama town, Oromia, Ethiopia.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!