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Optical detection of the spatial structural alteration in the human brain tissues/cells and DNA/chromatin due to Parkinson's disease.
ArXiv
December 2024
Department of Physics and Astronomy, Mississippi State University, Mississippi State, MS, USA, 39762.
Parkinson's disease (PD) is considered one of the most frequent neurological diseases in the world. There is a need to study the early and efficient biomarkers of Parkinson's, such as changes in structural disorders like DNA/chromatin, especially at the subcellular level in the human brain. We used two techniques, Partial wave spectroscopy (PWS) and Inverse Participation Ratio (IPR), to detect the changes in structural disorder in the human brain tissue samples.
View Article and Find Full Text PDFHeterodyne analysis of high-order partial waves in attosecond photoionization of helium.
Nat Commun
January 2025
State Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai, China.
Partial wave analysis is key to interpretation of the photoionization of atoms and molecules on the attosecond timescale. Here we propose a heterodyne analysis approach, based on the delay-resolved anisotropy parameters to reveal the role played by high-order partial waves during photoionization. This extends the Reconstruction of Attosecond Beating By Interference of Two-photon Transitions technique into the few-photon regime.
View Article and Find Full Text PDFHybrid Raman and Partial Wave Spectroscopy Microscope for the Characterization of Molecular and Structural Alterations in Tissue.
J Biophotonics
December 2024
Chair of Biological Imaging at the Central Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Munich, Germany.
We present a hybrid Raman spectroscopy (RS) and partial wave spectroscopy (PWS) microscope for the characterization of molecular and structural tissue alterations. The PWS performance was assessed with surface roughness standards, while the Raman performance with a silicon crystal standard. We also validated the system on stomach and intestinal mouse tissues, two closely-related tissue types, and demonstrate that the addition of PWS information improves RS data classification for these tissue types from R = 0.
View Article and Find Full Text PDFComputation of acoustic scattered fields and derived radiation force and torque for axisymmetric objects at arbitrary orientations.
J Acoust Soc Am
October 2024
Department of Mechanical Engineering, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
This study presents a theoretical framework for calculating acoustic scattering fields, as well as radiation force and torque resulting from the interaction between an incident wave and an axisymmetric object positioned at arbitrary orientations. Grounded in the partial-wave expansion method, it formulates scattering products using beam-shape and scalar scattering coefficients. The incorporation of geometric features into the scalar scattering coefficients is achieved through the conformal transformation approach.
View Article and Find Full Text PDFDeep Learning-driven Automatic Nuclei Segmentation of Label-free Live Cell Chromatin-sensitive Partial Wave Spectroscopic Microscopy Imaging.
bioRxiv
August 2024
Department of Electrical and Computer Engineering, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA.
Chromatin-sensitive Partial Wave Spectroscopic (csPWS) microscopy offers a non-invasive glimpse into the mass density distribution of cellular structures at the nanoscale, leveraging the spectroscopic information. Such capability allows us to analyze the chromatin structure and organization and the global transcriptional state of the cell nuclei for the study of its role in carcinogenesis. Accurate segmentation of the nuclei in csPWS microscopy images is an essential step in isolating them for further analysis.
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