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Deciphering the structural consequences of R83 and R152 methylation on DNA polymerase β using molecular modeling.
PLoS One
March 2025
Department of Physics, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates.
DNA polymerase β, a member of the X-family of DNA polymerases, undergoes complex regulations both in vitro and in vivo through various posttranslational modifications, including phosphorylation and methylation. The impact of these modifications varies depending on the specific amino acid undergoing alterations. In vitro, methylation of DNA polymerase β with the enzyme protein arginine methyltransferase 6 (PRMT6) at R83 and R152 enhances polymerase activity by improving DNA binding and processivity.
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CIMAP: Centre de recherche sur les ions les materiaux et la photonique, UMR 6252 CEA/CNRS/Unicaen/Ensicaen, GANIL, Bd Becquerel, 14070, CAEN, FRANCE.
The direct effects of ionizing radiation on antibiotics are largely unknown. Here, we report mass spectra of the cationic products of the irradiation of three antibiotics by carbon ions at 10.4 MeV kinetic energy.
View Article and Find Full Text PDFSocial neuropsychology of epilepsy in the digital age: A narrative review on challenges and opportunities.
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Swiss Epilepsy Center, Bleulerstrasse 60, Zurich 8008, Switzerland; University of Zurich, Department of Psychology, Binzmuehlestrasse 14, Zurich 8050, Switzerland. Electronic address:
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View Article and Find Full Text PDFChronic lymphocytic leukemia (CLL) screening and abnormality detection based on multi-layer fluorescence imaging signal enhancement and compensation.
J Cancer Res Clin Oncol
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School of Computer Science and Technology, Changchun University of Science and Technology, Changchun, 130032, China.
Purpose: Fluorescence in situ hybridization (FISH) plays a critical role in cancer screening but faces challenges in signal clarity and manual intervention. This study aims to enhance FISH signal clarity, improve screening efficiency, and reduce false negatives through an automated image acquisition and signal enhancement framework.
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Learning transition path and membrane topological signatures in the folding pathway of bacteriorhodopsin (BR) fragment with artificial intelligence.
J Chem Phys
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Department of Biological Science, Indian Institute of Science Education and Research (IISER), Kolkata, India.
Membrane protein folding in the viscous microenvironment of a lipid bilayer is an inherently slow process that challenges experiments and computational efforts alike. The folding kinetics is moreover associated with topological modulations of the biological milieu. Studying such structural changes in membrane-embedded proteins and understanding the associated topological signatures in membrane leaflets, therefore, remain relatively unexplored.
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