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Biomarkers.
Alzheimers Dement
December 2024
University of Southern California, Los Angeles, CA, USA.
Background: The apolipoprotein E (ApoE) Ɛ4 allele is associated with a significant risk for both late-onset Alzheimer's Disease (AD) development and cerebral amyloidosis, but the degree to which cerebrospinal fluid (CSF) apoE glycosylation affects disease progression is unclear. The objective of this study was to examine the relationship of CSF apoE glycosylation with t-tau, p-tau181, and Aβ1-42 CSF levels, and to delineate the effect of the APOE4+ genotype (vs E4-) on glycosylation.
Method: Total glycosylation and apoE isoform-specific glycosylation were analyzed in baseline plasma and CSF samples from a longitudinal cohort of older individuals (n=188, ages 55 - 89) from the Alzheimer's Disease Neuroimaging Initiative (ADNI).
Biomarkers.
Alzheimers Dement
December 2024
Dementia Research Centre, Queen Square Institute of Neurology, University College London, London, UK.
Background: GRN mutations are a common cause of frontotemporal dementia (FTD), with previous studies linking granulin deficiency to reduced bis(monoacylglycerol)phosphate (BMP) levels, which ultimately impairs ganglioside degradation. BMP is involved in the lysosomal functions within cells, as it facilitates the adhesion of hydrolases and activator proteins where the lysosomal membranes meet, therefore a lack of BMP could impact lysosome function and integrity. We hypothesised that urine levels of BMP isoforms will be lower in FTD patients with GRN haploinsufficiency, as a reflection of reduced BMP in neural tissues, when compared to those with FTD caused by C9orf72 expansions and MAPT mutations, or healthy controls.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, and Memory Clinic, Skåne University Hospital, Malmö, Sweden.
Background: Plasma phosphorylated tau (p-tau), particularly p-tau217, has demonstrated its reliability as a biomarker for diagnosing Alzheimer's disease (AD). Coming challenges in the field include determining whether quantifying additional plasma phosphorylated, and non-phosphorylated tau species could enhance diagnostic accuracy, prognosis, and improve patient monitoring by effectively staging the disease.
Method: We used a mass spectrometric targeted method to simultaneously quantify the levels of six different phosphorylated (p-tau 181, 199, 202, 205, 217 and 231), and six non-phosphorylated (0N CNS-specific, 1N CNS-specific, tau195-209, tau212-221, PNS-specific 7-14, PNS-specific 151-167) tau peptides in plasma.
Aim: To study the plasma proteome of patients with type 1 acute myocardial infarction (AMI) to identify potential markers for long-term prognosis of the risk for developing cardiovascular complications.
Material And Methods: The study included 64 patients with type 1 AMI with and without ST segment elevation who underwent primary percutaneous coronary intervention upon admission. The following information on cardiovascular events was collected for 36 months after admission: death from cardiovascular pathology, recurrent AMI, stroke, repeat myocardial revascularization and/or endarterectomy.
Identification of 3-methoxytyramine as a specific biomarker for beet-sugar-fed honey: A two year surveillance study in South Korea.
Food Res Int
January 2025
New Hazardous Substances Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Osong, Cheongju, Chungcheongbuk-do 28159, Republic of Korea. Electronic address:
Honey is highly vulnerable to food fraud, and there are growing concerns about product authenticity. The commonly used stable carbon isotope ratios in the Calvin (C3) and Hatch-Slack (C4) photosynthesis cycles in plant feed cannot distinguish between beet-sugar-fed honey and natural honey. However, 3-methoxytyramine (3-MT) can be used as specific biomarker for identifying adulteration of beet-sugar-fed honey.
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