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SPR is a fast and straightforward method to estimate the binding constants of cyclic dinucleotides to their binding partners, such as STING or poxin.
Biophys Chem
January 2025
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic. Electronic address:
The development of small molecule drugs that target protein binders is the central goal in medicinal chemistry. During the lead compound development process, hundreds or even thousands of compounds are synthesized, with the primary focus on their binding affinity to protein targets. Typically, IC or EC values are used to rank these compounds.
View Article and Find Full Text PDFAssessing stroke-induced abnormal muscle coactivation in the upper limb using the surface EMG co-contraction Index: A systematic review.
J Electromyogr Kinesiol
January 2025
Department of Rehabilitation Sciences, the Hong Kong Polytechnic University, Hong Kong Special Administrative Region of China. Electronic address:
Electromyography (EMG) is increasingly used in stroke assessment research, with studies showing that EMG co-contraction (EMG-CC) of upper limb muscles can differentiate stroke patients from healthy individuals and correlates with clinical scales assessing motor function. This suggests that EMG-CC has potential for both assessing motor impairments and monitoring recovery in stroke patients. However, systematic reviews on EMG-CC's effectiveness in stroke assessment are lacking.
View Article and Find Full Text PDFDevelopment of micro-nanostructured film with antibacterial, anticorrosive and thermal conductivity properties on copper surface.
Bioelectrochemistry
January 2025
Institute of Marine Science and Technology, Shandong University, Qingdao, Shandong 266237, China. Electronic address:
A micro-nano sharkskin like film (Cu-MNS-FA) was synthesized on copper surface through chemical etching followed by formate passivation, and its anticorrosive, antibacterial and thermal conductivity properties were investigated. Results show that after 7 d of exposure to nature, Pseudomonas aeruginosa and Desulfovibrio vulgaris seawater, the charge transfer resistance of Cu-MNS-FA is more than three times higher than that of unmodified copper. In particular, in D.
View Article and Find Full Text PDFRecent advances in graphitic carbon nitride-based nanocomposites for energy storage and conversion applications.
Nanotechnology
January 2025
Qingdao University, Ningxia Road 308, Qingdao, Shandong, 266071, CHINA.
Graphitic carbon nitride (g-C3N4) has gained significant attention as a promising nonmetallic semiconductor photocatalyst due to its photochemical stability, favorable electronic properties, and efficient light absorption. Nevertheless, its practical applications are hindered by limitations such as low specific surface area, rapid recombination of photogenerated charge carriers, poor electrical conductivity, and restricted photo-response ranges. This review explores recent advancements in the synthesis, modification and application of g-C3N4 and its nanocomposites with a focus on addressing these challenges.
View Article and Find Full Text PDFMachine Learning Potential for Identifying and Forecasting Complex Environmental Drivers of Infections in the United States.
Environ Health Perspect
January 2025
Centre for Environment, Fisheries and Aquaculture Science (CEFAS), Weymouth, UK.
Background: Environmental change in coastal areas can drive marine bacteria and resulting infections, such as those caused by , with both foodborne and nonfoodborne exposure routes and high mortality. Although ecological drivers of in the environment have been well-characterized, fewer models have been able to apply this to human infection risk due to limited surveillance.
Objectives: The Cholera and Other Illness Surveillance (COVIS) system database has reported infections in the United States since 1988, offering a unique opportunity to both explore the forecasting capabilities machine learning could provide and to characterize complex environmental drivers of infections.
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