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zIncubascope: Long-term quantitative imaging of multi-cellular assemblies inside an incubator.
PLoS One
January 2025
LP2N, Laboratoire Photonique Numérique et Nanosciences, University Bordeaux, Talence, France.
Recent advances in bioengineering have made it possible to develop increasingly complex biological systems to recapitulate organ functions as closely as possible in vitro. Monitoring the assembly and growth of multi-cellular aggregates, micro-tissues or organoids and extracting quantitative information is a crucial but challenging task required to decipher the underlying morphogenetic mechanisms. We present here an imaging platform designed to be accommodated inside an incubator which provides high-throughput monitoring of cell assemblies over days and weeks.
View Article and Find Full Text PDFMicroenvironment-confined kinetic elucidation and implementation of a DNA nano-phage with a shielded internal computing layer.
Nat Commun
January 2025
Institute of Molecular Medicine (IMM), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Multiple receptor analysis-based DNA molecular computation has been developed to mitigate the off-target effect caused by nonspecific expression of cell membrane receptors. However, it is quite difficult to involve nanobodies into molecular computation with programmed recognition order because of the "always-on" response mode and the inconvenient molecular programming. Here we propose a spatial segregation-based molecular computing strategy with a shielded internal computing layer termed DNA nano-phage (DNP) to program nanobody into DNA molecular computation and build a series of kinetic models to elucidate the mechanism of microenvironment-confinement.
View Article and Find Full Text PDFPalmitic Acid in the Diet of Dairy Goats and Its Effect on Physicochemical Characteristics and Fatty Acid Profile of Goat Kid Meat.
Anim Sci J
January 2025
General Terán Experimental Field, National Institute of Forestry, Agricultural and Livestock Research, General Terán, Mexico.
The objective of this study was to evaluate the impact of incorporating palmitic acid into the diet of dairy goats on the physicochemical characteristics, nutritional value, and fatty acid profile of goat kid meat. For this, 28 Creole local kids were used, divided into the following treatments: grazing, kids fed milk from grazing goats; base diet, kids fed milk from goats in confinement with a total mixed ration; base diet + 3PA, kids fed milk from goats in confinement that consumed the base diet plus 3% palmitic acid; and base diet + 6PA, kids fed milk from goats in confinement fed with the base diet plus 6% palmitic acid. The feeding period was conducted over a 30-day period.
View Article and Find Full Text PDFExceeding the limits of paediatric heat stress tolerance: the risk of losing a generation to climate inaction.
BMJ Paediatr Open
January 2025
Department of Population Health, New York University Grossman School of Medicine, New York, New York, USA
Greenhouse gas (GHG) emissions are creating unprecedented climate-driven extreme weather, with levels of heat and humidity surpassing human physiological tolerance for heat stress. These conditions create a risk of mass casualties, with some populations particularly vulnerable due to physiological, behavioural and socioeconomic conditions (eg, lack of adequate shelter, limited healthcare infrastructure, sparse air conditioning access and electrical grid vulnerabilities). Children, especially young children, are uniquely vulnerable to extreme heat-related morbidity and mortality due to factors including low body mass, high metabolism, suboptimal thermoregulatory mechanisms and behavioural vulnerabilities.
View Article and Find Full Text PDFQuantum Dot Luminescence Microspheres Enable Ultra-Efficient and Bright Micro-LEDs.
Adv Mater
January 2025
Fujian Key Laboratory of Surface and Interface Engineering for High Performance Materials, College of Materials, Xiamen University, Xiamen, 361005, P. R. China.
Quantum dot (QD)-converted micrometer-scale light-emitting diodes (micro-LEDs) are regarded as an effective solution for achieving high-performance full-color micro-LED displays because of their narrow-band emission, simplified mass transfer, facile drive circuits, and low cost. However, these micro-LEDs suffer from significant blue light leakage and unsatisfactory electroluminescence properties due to the poor light conversion efficiency and stability of the QDs. Herein, the construction of green and red QD luminescence microspheres with the simultaneously high conversion efficiency of blue light and strong photoluminescence stability are proposed.
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