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Extracorporeal Shock Waves Therapy for the Treatment of Acute and Chronic Wounds-A Prospective, Monocentric Clinical Trial to Examine the Effect of Shock Waves on Wound Healing.
Health Sci Rep
January 2025
Department of Plastic, Reconstructive and Aesthetic Surgery, Hand Surgery Martin-Luther Hospital (Martin-Luther Krankenhaus) Berlin Germany.
Introduction: The aim of our prospective blinded clinical study was to examine a possible improvement and acceleration of epithelialization by treatment with low-energy extracorporeal shock waves on skin graft donor and recipient sites in patients with chronic wounds. In addition, several secondary parameters were investigated to evaluate the compatibility of the therapeutic method, its influence on infection occurrence and bacterial colonization.
Materials And Methods: A total of 35 patients were included in the study.
Large, recursive membrane platforms are associated to Trop-1, Trop-2 and protein kinase signaling for cell growth.
Mol Biol Cell
January 2025
Laboratory of Cancer Pathology, Centre for Advanced Studies and Technology (CAST), University "G. D'Annunzio", Chieti, Italy.
The transmembrane glycoproteins Trop-1/EpCAM and Trop-2 independently trigger Ca and kinase signals for cell growth and tumor progression. Our findings indicated that Trop-1 and Trop-2 tightly colocalize at macroscopic, ruffle-like protrusions (RLP), that elevate from the cell perimeter, and locally recur over hundreds of seconds. These previously unrecognized elevated membrane regions ≥20 µm-long, up to 1.
View Article and Find Full Text PDFCriteria for identifying and evaluating locations that could potentially host the Cosmic Explorer observatories.
Rev Sci Instrum
January 2025
LIGO Hanford Observatory, Richland, Washington 99352, USA.
Cosmic Explorer is a next-generation ground-based gravitational-wave observatory that is being designed in the 2020s and is envisioned to begin operations in the 2030s together with the Einstein Telescope in Europe. The Cosmic Explorer concept currently consists of two widely separated L-shaped observatories in the United States, one with 40 km-long arms and the other with 20 km-long arms. This order of magnitude increase in scale with respect to the LIGO-Virgo-KAGRA observatories will, together with technological improvements, deliver an order of magnitude greater astronomical reach, allowing access to gravitational waves from remnants of the first stars and opening a wide discovery aperture to the novel and unknown.
View Article and Find Full Text PDFBackground: The associations between work-history trajectories and cognitive impairment among older adults were unknown. We investigated the association between work-history patterns and cognitive trajectories in later life.
Method: We conducted the study by using four regular waves and Life History survey in the Harmonized Dataset of the China Health and Retirement Longitudinal Study (CHARLS), included 5511 participants (47.
Background: Midlife cardiovascular risk factors (CVRF) are associated with late-life cognitive impairment, but also mortality. We evaluated their association with cognitive decline in a diverse cohort of older adults who survived to age 80 without diagnosis of dementia.
Method: Three harmonized cohorts of long-term Kaiser Permanente members were pooled and restricted to those aged 80+.
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