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Aptamer-Antibody Birecognized Sandwich SERRS Biosensor in Accurate and Rapid Identification of Intraoperative Parathyroid Hormone.
Anal Chem
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State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, College of Energy, Discipline of Intelligent Instrument and Equipment, Cancer Center and Department of Breast and Thyroid Surgery, Department of Ultrasound, Xiang'an Hospital of Xiamen University, School of Medicine, Laboratory Animal Center Xiamen University, Xiamen University, Xiamen 361005, China.
With the increasing incidence of thyroid cancer worldwide and the increasing demand for surgery, the risk of parathyroid injury is also increasing, which will lead to postoperative hypoparathyroidism (HP) and hypocalcemia. In order to improve the quality of life of patients after surgery, there is an urgent need to develop a novel platform that can identify the parathyroid gland immediately during surgery. The parathyroid gland promotes the increase of blood calcium concentration by secreting parathyroid hormone (PTH).
View Article and Find Full Text PDFInvestigation of the Impact of Thionine Functionalization on Magnetoelastic Sensor Performance.
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Departamento de Física, Universidade Federal de Viçosa, Viçosa, Minas Gerais 36570-900, Brasil.
This study investigates the functionalization of gold-coated magnetoelastic sensors with thionine molecules, focusing on resonance frequency shifts. The functionalization process was characterized by using Raman spectroscopy and analyzed via scanning electron microscopy and atomic force microscopy, revealing the progressive formation of molecular clusters over time. Our results demonstrate that longer functionalization time leads to saturation of surface coverage and cluster formation, impacting the sensor's resonance frequency shifts.
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View Article and Find Full Text PDFThe optical properties of the 1D nanograting chip have been explored based on computational and experimental studies. Dispersion curve analysis demonstrates cavity and surface plasmon modes in the 1D nanograting chips with periods of 400 nm and 800 nm. In this grating period range, the cut-off period is at a grating period of 644 nm under excitation with a wavelength of 670 nm.
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