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RECQL4 affects MHC class II-mediated signalling and favours an immune-evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melanoma.
Clin Transl Med
January 2025
Department of Dermatology and Allergy, University Hospital of Munich, Ludwig-Maximilian-University, Munich, Germany.
Background: Cancer immunotherapy has transformed metastatic cancer treatment, yet challenges persist regarding therapeutic efficacy. RECQL4, a RecQ-like helicase, plays a central role in DNA replication and repair as part of the DNA damage response, a pathway implicated in enhancing efficacy of immune checkpoint inhibitor (ICI) therapies. However, its role in patient response to ICI remains unclear.
View Article and Find Full Text PDFIsolated Tin Enhanced CO Coverage-Regulation on SnCu Alloy for Selective CO Electroreduction to C Products.
Small
January 2025
Institute of Advanced Wear & Corrosion Resistant and Functional Materials, Jinan University, Guangzhou, 510632, P. R. China.
Electricity-powered C─C coupling of CO represents an attractive strategy for producing valuable commodity chemicals with renewable energy, but it is still challenging to gain high C selectivity at high current density. Here, a SnCu single-atom alloy (SAA) is reported with isolated Sn atom embedded into the Cu lattice, as efficient ectrocatalyst for CO reduction. The as prepared SnCu-SAA catalyst shows a maximal C Faradaic efficiency of 79.
View Article and Find Full Text PDFProtein abundance of drug transporters and drug-metabolizing enzymes in paired healthy and tumor tissue from colorectal cancer patients.
Int J Pharm
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Drug Delivery and Disposition, KU Leuven, Gasthuisberg ON2, Herestraat 49 - box 921, 3000 Leuven, Belgium. Electronic address:
The widespread prevalence of colorectal cancer and its high mortality rate emphasize the urgent need for more effective therapies. When developing new drug products, a key aspect is ensuring that sufficiently high concentrations of the active drug are reached at the site of action. Drug transporters and drug-metabolizing enzymes can significantly influence the absorption and local accumulation of drugs in intestinal tissue.
View Article and Find Full Text PDFTowards enhancing phytoremediation: The effect of syringic acid, a plant secondary metabolite, on the presence of phenoxy herbicide-tolerant endophytic bacteria.
Sci Total Environ
January 2025
UNESCO Chair on Ecohydrology and Applied Ecology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Lodz, Poland.
Among emerging pollutants, residuals of phenoxy herbicides, including 2-chloro-4-methylphenoxy acid (MCPA), are frequently detected in non-targeted areas. MCPA can be removed from environmental matrices using biological remediation methods including endophyte-assisted phytoremediation. The interactions between selected plants excreting to the rhizosphere plant secondary metabolites (PSMs) and plant-associated bacteria (incl.
View Article and Find Full Text PDFPredictive modelling of acute Promyelocytic leukaemia resistance to retinoic acid therapy.
Brief Bioinform
November 2024
Department of Biology, École Normale Supérieure, 46 rue d'Ulm, 75005 Paris, France.
Acute Promyelocytic Leukaemia (APL) arises from an aberrant chromosomal translocation involving the Retinoic Acid Receptor Alpha (RARA) gene, predominantly with the Promyelocytic Leukaemia (PML) or Promyelocytic Leukaemia Zinc Finger (PLZF) genes. The resulting oncoproteins block the haematopoietic differentiation program promoting aberrant proliferative promyelocytes. Retinoic Acid (RA) therapy is successful in most of the PML::RARA patients, while PLZF::RARA patients frequently become resistant and relapse.
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