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Accelerating repair of infected bone defects through post-reinforced injectable hydrogel mediated antibacterial/immunoregulatory microenvironment at bone-hydrogel interface.
Carbohydr Polym
March 2025
Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital, Wuhan University, Wuhan 430000, China; Hubei Clinical Medical Research Center of Trauma and Microsurgery, Wuhan 430000, China. Electronic address:
Functional injectable hydrogel (IH) is promising for infected bone defects (IBDs) repair, but how to endow it with desired antibacterial/immunoregulatory functions as well as avoid mechanical failures during its manipulation has posed as main challenges. Herein, rosmarinic acid (RosA), a natural product with antibacterial/immunoregulatory activities, was utilized to develop a FCR IH through forming phenylboronic acid ester bonds with 4-formylphenyl phenylboronic acid (4-FPBA) grafted chitosan (CS) (FC). After being applied to the IBD site, the FCR IH was then injected with tobramycin (Tob) solution, another alkaline antibacterial drug, to induce in situ crystallization of the FC, endowing the resultant FCRT hydrogel with adaptively enhanced mechanical strength and structural stability.
View Article and Find Full Text PDFAn Amorphous Donor-Acceptor Conjugated Polymer with Both High Charge Carrier Mobility and Luminescence Quantum Efficiency.
Angew Chem Int Ed Engl
January 2025
Oxford University: University of Oxford, Department of Chemistry, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
Organic semiconducting polymers play a pivotal role in the development of field-effect transistors (OFETs) and organic light-emitting diodes (OLEDs), owing to their cost-effectiveness, structural versatility, and solution processability. However, achieving polymers with both high charge carrier mobility (μ) and photoluminescence (PL) quantum yield (Φ) remains a challenge. In this work, we present the design and synthesis of a novel donor-acceptor π-conjugated polymer, TTIF-BT, featuring a di-Thioeno[3,2-b] ThioenoIndeno[1,2-b] Fluorene (TTIF) backbone as the donor component.
View Article and Find Full Text PDFMolecular phylogeny and morphology reveal three new plant pathogenic fungi species (Septobasidiales, Basidiomycota) from China.
MycoKeys
December 2024
Yunnan Provincial Key Laboratory for Conservation and Utilization of In-forest Resource, the Key Laboratory of Forest Resources Conservation and Utilization in the Southwest Mountains of China Ministry of Education, Southwest Forestry University, Kunming 650224, China Southwest Forestry University Kunming China.
Three new fungal species, , and , are proposed based on a combination of the morphological features and molecular evidence. The taxon is characterized by the coriaceous basidiomata with a cream surface, cylindrical basidia, straight, 4-celled, subglobose or ovoid probasidia and thin-walled, narrowly cylindrical basidiospores with septa, measuring as 7-9 × 3.5-4.
View Article and Find Full Text PDFUS Real-World Effectiveness, Tolerability, and Healthcare Resource Utilization After Addition of Fremanezumab for Preventive Treatment in Patients Using Gepants for Acute Treatment of Migraine: Results From a Retrospective Chart Review.
Adv Ther
January 2025
Dent Neurologic Institute, 3980 Sheridan Dr., Amherst, NY, 14226, USA.
Introduction: Fremanezumab, a monoclonal antibody (mAb) targeting the calcitonin gene-related peptide (CGRP) pathway, and gepants, small molecule CGRP receptor antagonists, are both approved for the treatment of migraine or its symptoms. This study assessed effectiveness, tolerability, and migraine-related healthcare resource utilization (HCRU) after the addition of fremanezumab for preventive migraine treatment in patients using gepants for acute treatment.
Methods: Data were extracted during a retrospective chart review from electronic medical records from the Dent Neurologic Institute.
Ascertaining provider-level implicit bias in electronic health records with rules-based natural language processing: A pilot study in the case of prostate cancer.
PLoS One
January 2025
Department of Urology, NewYork-Presbyterian Hospital/Weill Cornell Medical Center, New York, New York, United States of America.
Purpose: Implicit, unconscious biases in medicine are personal attitudes about race, ethnicity, gender, and other characteristics that may lead to discriminatory patterns of care. However, there is no consensus on whether implicit bias represents a true predictor of differential care given an absence of real-world studies. We conducted the first real-world pilot study of provider implicit bias by evaluating treatment parity in prostate cancer using unstructured data-the most common way providers document granular details of the patient encounter.
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