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Intelligent sequential degradation hydrogels by releasing bimetal-phenolic for enhanced diabetic wound healing.
J Control Release
January 2025
Department of Plastic Surgery and Burn Center, Second Affiliated Hospital, Shantou University Medical College, Shantou, Guangdong 515051, China; Plastic Surgery Institute of Shantou University Medical College, Shantou, Guangdong 515051, China; Research Center of Translational Medicine, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515051, China. Electronic address:
Healing of diabetic wounds is significantly impeded by a complex environment comprising biofilm formation, excessive inflammation, and compromised angiogenic capacity, leading to a disordered physiological healing process. Restoration and maintenance of a normal and orderly healing process in diabetic wounds remain unmet therapeutic objectives. Herein, an innovative bimetal-phenolic network hydrogel system is designed with a concentric circular structure, enabling dual-drug delivery with differentiated release kinetics.
View Article and Find Full Text PDFIntelligent optoelectrowetting digital microfluidic system for real-time selective parallel manipulation of biological droplet arrays.
Lab Chip
December 2024
School of Mechanical and Electrical Engineering, Hainan University, Haikou 570228, Hainan, China.
Article Synopsis
- Optoelectrowetting technology allows for the manipulation of droplets by creating virtual electrodes, avoiding complicated physical circuitry in droplet control systems.
- Current limitations include the need for manual droplet positioning and lack of real-time feedback, which can lead to mismanagement and contamination of droplets.
- The paper introduces an intelligent control system that integrates optoelectrowetting with deep learning for real-time detection and automatic movement control of droplets, improving flexibility and accuracy in experiments, especially in biomedicine.
Effect of rapid maxillary expansion on nasomaxillary structure and sleep disordered breathing in children with obstructive sleep apnoea.
Aust Dent J
December 2024
Department of Clinical Sciences and Translational Medicine, University Tor Vergata, Rome, Italy.
Objective: The aim of this study was to assess the effect of RME on upper airway structure and its relationship to improvements in sleep disordered breathing.
Methods: The study was carried out in 23 children with malocclusion and OSA. Clinical assessment visits, daytime sleepiness questionnaire, polysomnography and orthognatodontic examination were performed before (T0) and 4 (T1) and 12 (T2) months after RME.
Multifunctional injectable hydrogel system as a mild photothermal-assisted therapeutic platform for programmed regulation of inflammation and osteo-microenvironment for enhanced healing of diabetic bone defects .
Theranostics
December 2024
Department of Spine Surgery and Musculoskeletal Tumor, Zhongnan Hospital of Wuhan University, 168 Donghu Street, Wuchang District, Wuhan 430071 Hubei, China.
Article Synopsis
- Factor-free biomaterial scaffolds are crucial for bone repair, but diabetes complicates healing due to issues like oxidative stress and infection.
- A new multifunctional platform called GAD/MC, using copper-containing TiCT MXene nanosheets and hydrogels, aims to improve therapy for bone defects in diabetic patients.
- This platform features enhanced mechanical properties, self-healing abilities, and can release bioactive copper in response to environmental changes, promoting antibacterial effects and reducing inflammation to support healing.
SOP-MULTI: A Self-Organized Polymer-Based Coarse-Grained Model for Multidomain and Intrinsically Disordered Proteins with Conformation Ensemble Consistent with Experimental Scattering Data.
J Chem Theory Comput
November 2024
Molecular Biophysics Unit, Indian Institute of Science, Bangalore, Karnataka 560012, India.
Article Synopsis
- Multidomain proteins and intrinsically disordered proteins (IDPs) are characterized by a range of conformations rather than fixed structures, making their high-resolution analysis difficult.
- Integrative methods that merge low-resolution experimental data with computer simulations are now commonly used to overcome these challenges, although simulating larger proteins with both folded and disordered sections remains complex.
- The SOP-MULTI force field introduced in this work enhances the simulation of such proteins by combining established models for folded and disordered proteins, allowing for accurate representation of their conformational ensembles and maintaining essential structural features.
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