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Effects of intra-tumoral cellular heterogeneity of oxygen partial pressure on biological effectiveness of hydrogen-, helium-, carbon-, oxygen-, and neon-ion beams.
Phys Med Biol
January 2025
Department of Accelerator and Medical Physics, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, JAPAN.
The tumor microenvironment characterized by heterogeneously organized vasculatures causes intra-tumoral heterogeneity of oxygen partial pressure at the cellular level, which cannot be measured by current imaging techniques. The intra-tumoral cellular heterogeneity may lead to a reduction of therapeutic effects of radiation. The purpose of this study was to investigate the effects of the heterogeneity on biological effectiveness of H-, He-, C-, O-, and Ne-ion beams for different oxygenation levels, prescribed dose levels, and cell types.
View Article and Find Full Text PDFCompound electron acceleration at planetary foreshocks.
Nat Commun
January 2025
NASA Goddard Space Flight Center, Heliophysics Science Division, Greenbelt, MD, USA.
Shock waves, the interface of supersonic and subsonic plasma flows, are the primary region for charged particle acceleration in multiple space plasma systems, including Earth's bow shock, which is readily accessible for in-situ measurements. Spacecraft frequently observe relativistic electron populations within this region, characterized by energy levels surpassing those of solar wind electrons by a factor of 10,000 or more. However, mechanisms of such strong acceleration remain elusive.
View Article and Find Full Text PDFPrognostic Significance of Plasma Soluble IL-6 Receptor in Carbon-ion Radiotherapy for Pancreatic Cancer.
Anticancer Res
January 2025
Department of Charged Particle Therapy Research, National Institutes for Quantum Science and Technology, Chiba, Japan
Background/aim: For patients with unresectable locally advanced pancreatic cancer (LAPC), carbon-ion radiotherapy (C-ion RT) can safely deliver higher doses than conventional photon therapy, increasing the potential for long-term survival. However, achieving meaningful improvements in survival rates requires reliable prognostic biomarkers to identify patients likely to benefit from treatment.
Patients And Methods: In this study, we measured plasma levels of soluble interleukin-6 receptor (sIL-6R) before C-ion RT and examined their association with the risk of distant metastasis (DM), local recurrence (LR), and overall survival (OS).
Synchrotron-based infrared microspectroscopy unveils the biomolecular response of healthy and tumour cell lines to neon minibeam radiation therapy.
Analyst
December 2024
Physics Department, Universitat Autònoma de Barcelona (UAB), 08193 Cerdanyola del Vallès, Barcelona, Spain.
Radioresistant tumours remain complex to manage with current radiotherapy (RT) techniques. Heavy ion beams were proposed for their treatment given their advantageous radiobiological properties. However, previous studies with patients resulted in serious adverse effects in the surrounding healthy tissues.
View Article and Find Full Text PDFSimulation of the charged particle deflection from the sweeping magnet array in the Lunar Environment heliospheric X-ray imager.
Rev Sci Instrum
December 2024
662, NASA Goddard Space Flight Center, Greenbelt, Maryland 20771, USA.
Article Synopsis
- The Lunar Environment heliospheric X-ray Imager (LEXI) is designed to capture x-ray images from solar wind interactions in Earth's magnetosheath, helping researchers understand energy transfer into Earth's magnetosphere.
- As part of a lunar lander mission landing in Mare Crisium, LEXI features a unique array of 48 neodymium magnets to protect against interference from charged particles while minimizing stray magnetic fields.
- A Runge-Kutta-based simulation model shows that LEXI's deflector array and other particle suppression methods effectively limit proton and electron contamination, ensuring the success of its imaging capabilities and offering insights for similar instruments.
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