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Background: Pharmacy internships are an important part of pharmacy education in Poland; they are an integral part of professional studies. The first two internships are held after the third and fourth year of study during the summer break and last for four weeks. The study aims to analyze the didactic process of the pharmacy students taking place during the summer internship in community and hospital pharmacies in Poland.

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Phosphate rebinding induces force reversal via slow backward cycling of cross-bridges.

Front Physiol

January 2025

Institute of Vegetative Physiology, University of Cologne, Köln, Germany.

Objective: Previous studies on muscle fibers, myofibrils, and myosin revealed that the release of inorganic phosphate (P) and the force-generating step(s) are reversible, with cross-bridges also cycling backward through these steps by reversing force-generating steps and rebinding P. The aim was to explore the significance of force redevelopment kinetics (rate constant ) in cardiac myofibrils for the coupling between the P binding induced force reversal and the rate-limiting transition for backward cycling of cross-bridges from force-generating to non-force-generating states.

Methods: and force generation of cardiac myofibrils from guinea pigs were investigated at 0.

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Dogs are a susceptible species to human adenovirus 36 infection: New insights into the host range of the virus causing infectious obesity.

Vet Microbiol

January 2025

Division of Microbiology, Department of Pathology, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, C.K. Norwida 31 Street, Wrocław 50-375, Poland. Electronic address:

The prevalence of obesity within the human population is escalating globally yearly. Obesity constitutes a complex ailment with diverse etiological factors. Recently, the infectious side of obesity aetiology, implicating pathogens such as human adenovirus 36 (HAdV-D36), has gained attention.

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To clarify the effect of the fluorine atom and piperazine ring on norfloxacin (NOR), NOR degradation products (NOR-DPs, P1-P8) were generated via UV combined with hydrogen peroxide (UV/HO) technology. NOR degradation did not significantly affect cytotoxicity of NOR against BV2, A549, HepG2, and Vero E6 cells. Compared with that of NOR, mutagenicity and median lethal concentration of P1-P8 in fathead minnow were increased, and bioaccumulation factor and oral median lethal dose of P1-P8 in rats were decreased.

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Gauge Invariance of Equilibrium Statistical Mechanics.

Phys Rev Lett

November 2024

Theoretische Physik II, Physikalisches Institut, Universität Bayreuth, D-95447 Bayreuth, Germany.

We identify a recently proposed shifting operation on classical phase space as a gauge transformation for statistical mechanical microstates. The infinitesimal generators of the continuous gauge group form a noncommutative Lie algebra, which induces exact sum rules when thermally averaged. Gauge invariance with respect to finite shifting is demonstrated via Monte Carlo simulation in the transformed phase space which generates identical equilibrium averages.

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