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miR-208a-3p discriminates osteoporosis, predicts fracture, and regulates osteoclast activation through targeting STC1.
J Orthop Surg Res
January 2025
Department of Rehabilitation, The Affiliated Hospital of Youjiang Medical University for Nationalities, No.18, Zhongshan 2nd Road, Baise, 533000, Guangxi Zhuang Autonomous Region, China.
Background: Osteoporosis (OP) frequently occurs in post-menopausal women, increasing the risk of fracture. Early screening OP could improve the prevention of fractures.This study focused on the significance of miR-208a-3p in diagnosing OP and development regulation, aiming to explore a novel biomarker and therapeutic target for OP.
View Article and Find Full Text PDFSex-specific effects on the heart from combined exposure to simulated galactic cosmic radiation and hindlimb unloading.
Life Sci Space Res (Amst)
February 2025
Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Future long duration space missions will expose astronauts to higher doses of galactic cosmic radiation (GCR) than those experienced on the international space station. Recent studies have demonstrated astronauts may be at risk for cardiovascular complications due to increased radiation exposure and fluid shift from microgravity. However, there is a lack of direct evidence on how the cardiovascular system is affected by GCR and microgravity since no astronauts have been exposed to exploratory mission relevant GCR doses.
View Article and Find Full Text PDFThe moderating and mediating role of the placenta in the association between prenatal exposure to air pollutants and birth weight: A twin study.
Environ Res
January 2025
Department of Epidemiology, NUTRIM School for Translational Research in Metabolism, Maastricht University Medical Centre, P.O. Box 616, 6200 MD Maastricht, The Netherlands. Electronic address:
Prenatal exposure to air pollution has been linked to lower birth weight, yet the role of the placenta in this association is often overlooked. This study investigates whether placental characteristics act as moderators or mediators in the association between prenatal exposure to particulate matter (PM) and nitrogen dioxide (NO) and birth weight in twins. The study included 3340 twins (born 2002-2013) from the East Flanders Prospective Twin Survey.
View Article and Find Full Text PDFIdentification and regulation of a novel leptin receptor-linked enhancer during zebrafish ventricle regeneration.
Life Sci
January 2025
TaiKang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan, China; Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan, China. Electronic address:
Aims: Vertebrates vary greatly in their abilities to regenerate injured hearts. Zebrafish possess a remarkable capacity for cardiac regeneration, making them an excellent model for regeneration research. Recent studies have reported the activation and underlying regulatory mechanisms of leptin b (lepb) and the leptin b-linked enhancer (LEN) in injured hearts.
View Article and Find Full Text PDFResearch motivation as a mediating variable between system intelligence, academic grit, and academic achievement among postgraduate students, faculty of education, Zagazig University.
BMC Psychol
January 2025
Educational Psychology Department, Faculty of Education, Zagazig University, Sharkia, Egypt.
Background: Recent years have witnessed a revolutionary transformation in information technology, characterized by the proliferation of electronic information platforms, with the Egyptian Knowledge Bank being a notable example. Understanding how to effectively navigate these complex systems requires investigation into key factors, particularly system intelligence.
Objectives: This study aimed to examine the mediating role of research motivation in the relationship between system intelligence, Academic Grit, and Academic Achievement.
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