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Quantitative risk assessment of rainstorm-induced flood disaster in Piedmont plain of Pakistan.
Sci Rep
January 2025
State Key Laboratory of Geohazard Prevention and GeoEnvironment Protection, Chengdu University of Technology, Chengdu, 610059, Sichuan, China.
Pakistan's geographic location makes it an important land hub between Central Asia, Middle East-North Africa, and China. However, the railways, roads, farmland, riverways, and residential quarters in the Piedmont plains of Baluchistan province in northwestern Pakistan are under serious threat of flooding in the summer of 2022. The urgency and severity of climate change's impact on humanity are underscored by the significant threats posed to human life and property in Piedmont Plains environments through extreme flood events, which has garnered widespread concerns.
View Article and Find Full Text PDFAb initio machine-learning unveils strong anharmonicity in non-Arrhenius self-diffusion of tungsten.
Nat Commun
January 2025
Institute for Materials Science, University of Stuttgart, D-70569, Stuttgart, Germany.
The knowledge of diffusion mechanisms in materials is crucial for predicting their high-temperature performance and stability, yet accurately capturing the underlying physics like thermal effects remains challenging. In particular, the origin of the experimentally observed non-Arrhenius diffusion behavior has remained elusive, largely due to the lack of effective computational tools. Here we propose an efficient ab initio framework to compute the Gibbs energy of the transition state in vacancy-mediated diffusion including the relevant thermal excitations at the density-functional-theory level.
View Article and Find Full Text PDFFracture resistance and marginal fit of three different overlay designs using advanced zirconia-reinforced lithium disilicate CAD/CAM material.
BMC Oral Health
January 2025
Department of Conservative Dentistry, Faculty of Dentistry, Alexandria University, Alexandria, Egypt.
Background: Conservative dentistry introduced modern restoration designs, contributing to the greater use of partial-coverage ceramic restorations. New strong bondable ceramic materials made fabricating partial coverage ceramic restorations easier to restore the badly destructed teeth.
Aim Of The Study: This study investigated the impact of three distinct overlay preparation designs on the marginal fit (both before and after thermal aging) and the fracture resistance of overlay restorations fabricated using advanced zirconia-reinforced lithium disilicate (ALD) CAD/CAM glass-ceramic blocks.
Prolactin in sleep and EEG regulation: new mechanisms and sleep-related brain targets complement classical data.
Neurosci Biobehav Rev
January 2025
Laboratory of Molecular and Systems Neurobiology, Department of Physiology and Neurobiology, Eötvös Loránd University.
The role of prolactin in sleep regulation has been the subject of extensive research over the past 50 years, resulting in the identification of multiple, disparate functions for the hormone. Prolactin demonstrated a characteristic circadian release pattern with elevation during dark and diminution during light. High prolactin levels were linked to non-rapid eye movement sleep and electroencephalogram delta activity in humans.
View Article and Find Full Text PDFSingle-nucleus transcriptome profiling provides insights into the pathophysiology of adhesive arachnoiditis.
Biochim Biophys Acta Mol Basis Dis
January 2025
Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. Electronic address:
Adhesive arachnoiditis (AA) is a rare form of chronic degenerative pathology associated with persistent inflammation in the arachnoid matter of the spinal cord. Despite the existing knowledge, the detailed pathological mechanisms underlying AA are not fully understood. This study aimed to elucidate through comprehensive single nuclei RNA sequencing (snRNA-seq) to delineate the transcriptomic landscape of AA.
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