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Opioid withdrawal syndrome induced by naldemedine administration in a cancer patient without brain metastasis.
Palliat Support Care
March 2025
Departments of Psycho-oncology, Saitama Medical University International Medical Center, Saitama, Japan.
Objectives: Naldemedine is a peripherally acting μ-opioid receptor antagonist used to treat opioid-induced constipation. As this drug does not cross the blood-brain barrier, it is believed that patients without brain metastases do not experience opioid withdrawal symptoms.
Methods: Here, we experienced a case in which a cancer patient without brain metastasis presented with anxiety and restlessness that was severe enough to interfere with daily life.
The Need to Distinguish between "Lapse" and "Relapse".
Perspect Behav Sci
March 2025
Sorenson Center for Clinical Excellence, 6405 Old Main Hill, Logan, UT 84321 USA.
Over the last decade, behavior analysts have become increasingly interested in relapse and have used the term to describe the reemergence of problem behavior following successful reductions achieved during clinical intervention. Nonetheless, some elements of the current terminology may interfere with behavior analysts' efforts to examine, predict, and mitigate the conditions that lead to the reemergence of severe problem behavior in clinical settings. The current article (1) describes how the term "relapse" has been used in the field of behavior analysis and fails to capture more nuanced effects observed in the reemergence of problem behavior; (2) suggests use of the terms "lapse" and "relapse" to capture these distinct effects; and (3) outlines the positive impact enhanced technological distinction between the concept of "lapse" and "relapse" could have on clinical research and practice.
View Article and Find Full Text PDFImpact of Marasmic Malnutrition on Visceral Leishmaniasis: Progression and Treatment Efficacy in a Murine Model.
Nutrients
February 2025
Laboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro 21040-360, Brazil.
Background/objectives: Malnutrition and visceral leishmaniasis are major public health problems that are responsible for millions of deaths across many countries. Leishmaniasis development and progression are associated with the host immune status. In this context, malnutrition can directly affect the course of leishmaniasis, impairing several components of the immune system.
View Article and Find Full Text PDFMolecular Docking of Lactoferrin with Apoptosis-Related Proteins Insights into Its Anticancer Mechanism.
Int J Mol Sci
February 2025
Facultad de Ciencias Químicas, Universidad Autónoma de Chihuahua, Campus II Circuito Universitario s/n, Chihuahua 31125, Mexico.
Human Lactoferrin (hLf), a multifunctional glycoprotein, has been analyzed through molecular docking to evaluate its role in apoptosis regulation and its potential as an anticancer agent. The docking results highlight XIAP (X-linked Inhibitor of Apoptosis Protein) and Caspase-3 as the most reliable targets, where hLf disrupts XIAP's inhibition of Caspase-3 and Caspase-9, potentially restoring apoptotic signaling; hLf also stabilizes Caspase-3, enhancing its activation in intrinsic and extrinsic pathways. Weaker interactions were observed with Fas, Bcl-2, and Akt.
View Article and Find Full Text PDFJuvenile Hormone and Ecdysteroids Facilitate the Adult Reproduction Through the Gene and Gene in the Female .
Int J Mol Sci
February 2025
State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Insects, as the most diverse and numerous group in the animal kingdom, are at least partly dependent on the reproduction process, which is strictly regulated by the 'classic' insect hormones: juvenile hormone (JH), and 20-hydroxyecdysone (20E). However, the regulatory mechanism governing the reproduction of JH and 20E in remains unclear. In this study, ovarian development and ovulation in female were assessed through dissection of the ovaries following treatment with JH analog (JHA) and 20E.
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