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Integrating representation learning, permutation, and optimization to detect lineage-related gene expression patterns.
Nat Commun
January 2025
Laboratory for Information and Decision Systems, Massachusetts Institute of Technology, Cambridge, MA, USA.
Recent barcoding technologies allow reconstructing lineage trees while capturing paired single-cell RNA-sequencing (scRNA-seq) data. Such datasets provide opportunities to compare gene expression memory maintenance through lineage branching and pinpoint critical genes in these processes. Here we develop Permutation, Optimization, and Representation learning based single Cell gene Expression and Lineage ANalysis (PORCELAN) to identify lineage-informative genes or subtrees where lineage and expression are tightly coupled.
View Article and Find Full Text PDFSubclavian steal syndrome (SSS) often goes undiagnosed because of its variable and subtle symptoms, highlighting the need for innovative diagnostic approaches. This case report explores the integration of traditional Chinese medicine (TCM) in both diagnosing and managing SSS, marking a pioneering contribution to the field. An 80-year-old woman with persistent dizziness, unresponsive to conventional treatments, underwent TCM pulse diagnosis, which revealed significant inter-arm pulse discrepancies.
View Article and Find Full Text PDFOptimization Study of a High-Efficiency Preservative for Ammonia-Free Concentrated Natural Rubber Latex.
Polymers (Basel)
January 2025
Hainan Natural Rubber Technology Innovation Center, Rubber Research Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
Ammonia is commonly used as a preservative in the production of concentrated natural rubber latex (CNRL) and latex products; however, it poses a serious risk to human health and the environment. In this study, we investigated a thioacetamide derivative (TD) as a preservative of ammonia-free CNRL and the optimization of a stabilization system comprising potassium hydroxide (KOH), lauric acid (LA), and sodium dodecyl sulfate (SDS) to enhance its preservation effect. The results revealed that an optimal amount of TD (0.
View Article and Find Full Text PDFA Parallel Image Denoising Network Based on Nonparametric Attention and Multiscale Feature Fusion.
Sensors (Basel)
January 2025
School of Electronic and Information Engineering, Ankang University, Ankang 725000, China.
Convolutional neural networks have achieved excellent results in image denoising; however, there are still some problems: (1) The majority of single-branch models cannot fully exploit the image features and often suffer from the loss of information. (2) Most of the deep CNNs have inadequate edge feature extraction and saturated performance problems. To solve these problems, this paper proposes a two-branch convolutional image denoising network based on nonparametric attention and multiscale feature fusion, aiming to improve the denoising performance while better recovering the image edge and texture information.
View Article and Find Full Text PDFExploring the clinical value of procalcitonin, c-reactive protein, white blood cell count, and neutrophil-to-lymphocyte ratio in the early diagnosis of bloodstream infections in children.
BMC Pediatr
January 2025
Department of Clinical Laboratory, Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, 350000, China.
Backgroud: In the diagnosis of bloodstream infections (BSI) in children, compared to the gold standard of blood culture, markers in the blood offer advantages such as rapid results and cost-effectiveness. Therefore, we investigated the clinical value of procalcitonin (PCT), C-reactive protein (CRP), white blood cell count (WBC), and neutrophil-to-lymphocyte ratio (NLR) in the early diagnosis of BSI in children.
Methods: This study included a retrospective analysis of 309 suspected BSI cases and patients were categorized into 2 groups based on blood culture results: blood culture-positive group, and blood culture-negative group.
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