Thirty-seven untreated Parkinsonism patients showed significant positive correlations among decreased excretion of free dopamine, MMPI scores indicative of schizophrenic-like looseness of thinking, and the severity of all Parkinsonism signs except tremor. The data could indicate that abnormalities of dopamine metabolism may underlie both the motor and mental abnormalities of Parkinsonism.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC492496PMC
http://dx.doi.org/10.1136/jnnp.39.10.941DOI Listing

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