Thirty-seven untreated Parkinsonism patients showed significant positive correlations among decreased excretion of free dopamine, MMPI scores indicative of schizophrenic-like looseness of thinking, and the severity of all Parkinsonism signs except tremor. The data could indicate that abnormalities of dopamine metabolism may underlie both the motor and mental abnormalities of Parkinsonism.
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http://dx.doi.org/10.1136/jnnp.39.10.941 | DOI Listing |
Mov Disord
January 2025
Department of Neurology and Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA.
Front Cardiovasc Med
December 2024
Department of Cardiology, INSERM UMR 1295, Toulouse University Hospital, Toulouse, France.
Cerebrotendinous xanthomatosis (CTX) is a rare but treatable inherited neurometabolic disorder that can lead to severe sequelae if left untreated. Chenodeoxycholic acid is a safe and effective treatment for CTX. Early diagnosis is essential to improve patient outcomes.
View Article and Find Full Text PDFJ Neuroimmune Pharmacol
December 2024
Gene Therapy for CNS Disorders Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.
Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra that primarily affects movement control. Neuroinflammation plays a pivotal role in driving the disease's progression. The persistent inflammatory state in the brain exacerbates neuronal damage, creating a cycle that perpetuates the neurodegenerative process.
View Article and Find Full Text PDFJ Neurol
December 2024
Division of Physiotherapy, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
Background: Postural instability is considered a late complication of Parkinson's disease (PD). However, growing evidence shows that balance and gait problems may occur early in the disease.
Objective: To describe balance, gait, and falls/near falls in persons with newly diagnosed, untreated PD ("de novo"), and to compare this with persons with mild-moderate PD (Later PD).
Nucl Med Biol
November 2024
Amsterdam UMC location Vrije Universiteit Amsterdam, Dept Radiology & Nuclear Medicine, De Boelelaan 1117, Amsterdam, the Netherlands; Amsterdam Neuroscience, Brain Imaging, Amsterdam, the Netherlands. Electronic address:
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