A patient with systemic lupus erythematosus (SLE) developed attacks of unilateral cataplexy precipitated by laughter. Unilateral cataplexy has not been described previously in detail and its association with SLE is unique. The clinical details, investigations, and diagnostic criteria are discussed and a causal relationship between cataplexy and SLE is suggested.
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http://dx.doi.org/10.1136/jnnp.39.10.1023 | DOI Listing |
Eur J Neurosci
March 2013
Research Service, VA Boston Healthcare System, Brockton, MA, USA.
Dysfunction of the orexin/hypocretin neurotransmitter system causes the sleep disorder narcolepsy, characterized by intrusion of rapid eye movement (REM) sleep-like events into normal wakefulness. The sites where orexins act to suppress REM sleep are incompletely understood. Previous studies suggested that the lateral pontomesencephalic tegmentum (lPMT) contains an important REM sleep inhibitory area, and proposed that orexins inhibit REM sleep via orexin type 2 receptors (OxR2) in this region.
View Article and Find Full Text PDFEur J Neurosci
November 2010
Research Service, VA Boston Healthcare System, and Department of Psychiatry, Harvard Medical School, Brockton, MA 02301,USA.
The locus coeruleus (LC) regulates sleep/wakefulness and is densely innervated by orexinergic neurons in the lateral hypothalamus. Here we used small interfering RNAs (siRNAs) to test the role of LC orexin type 1 receptor (OxR1) in sleep–wake control. In sleep studies, bilateral OxR1 siRNA injections led to an increase of time spent in rapid eye movement (REM) sleep, which was selective for the dark (active) period, peaked at approximately 30% of control during the second dark period after injection and then disappeared after 4 days.
View Article and Find Full Text PDFJ Clin Sleep Med
February 2010
Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA.
I report a case of a 50-year-old African American woman who presented for a sleep medicine evaluation complaining of excessive daytime sleepiness of greater than 10 years' duration. She reported falling asleep while driving, talking with friends, and eating. Her Epworth Sleepiness Scale score was 21/24.
View Article and Find Full Text PDFPsychiatry Clin Neurosci
June 2001
Center for Narcolepsy, Sleep Research Center, Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, California, USA.
Periodic leg movements during sleep (PLMS) is a high prevalent sleep disorder of unknown etiology. The disease is pharmacologically treated with dopaminergic agonists (i.e.
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