A patient with systemic lupus erythematosus (SLE) developed attacks of unilateral cataplexy precipitated by laughter. Unilateral cataplexy has not been described previously in detail and its association with SLE is unique. The clinical details, investigations, and diagnostic criteria are discussed and a causal relationship between cataplexy and SLE is suggested.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC492507PMC
http://dx.doi.org/10.1136/jnnp.39.10.1023DOI Listing

Publication Analysis

Top Keywords

unilateral cataplexy
12
systemic lupus
8
lupus erythematosus
8
cataplexy associated
4
associated systemic
4
erythematosus patient
4
patient systemic
4
erythematosus sle
4
sle developed
4
developed attacks
4

Similar Publications

Dysfunction of the orexin/hypocretin neurotransmitter system causes the sleep disorder narcolepsy, characterized by intrusion of rapid eye movement (REM) sleep-like events into normal wakefulness. The sites where orexins act to suppress REM sleep are incompletely understood. Previous studies suggested that the lateral pontomesencephalic tegmentum (lPMT) contains an important REM sleep inhibitory area, and proposed that orexins inhibit REM sleep via orexin type 2 receptors (OxR2) in this region.

View Article and Find Full Text PDF

Knockdown of orexin type 1 receptor in rat locus coeruleus increases REM sleep during the dark period.

Eur J Neurosci

November 2010

Research Service, VA Boston Healthcare System, and Department of Psychiatry, Harvard Medical School, Brockton, MA 02301,USA.

The locus coeruleus (LC) regulates sleep/wakefulness and is densely innervated by orexinergic neurons in the lateral hypothalamus. Here we used small interfering RNAs (siRNAs) to test the role of LC orexin type 1 receptor (OxR1) in sleep–wake control. In sleep studies, bilateral OxR1 siRNA injections led to an increase of time spent in rapid eye movement (REM) sleep, which was selective for the dark (active) period, peaked at approximately 30% of control during the second dark period after injection and then disappeared after 4 days.

View Article and Find Full Text PDF

I report a case of a 50-year-old African American woman who presented for a sleep medicine evaluation complaining of excessive daytime sleepiness of greater than 10 years' duration. She reported falling asleep while driving, talking with friends, and eating. Her Epworth Sleepiness Scale score was 21/24.

View Article and Find Full Text PDF

Narcoleptic canines display periodic leg movements during sleep.

Psychiatry Clin Neurosci

June 2001

Center for Narcolepsy, Sleep Research Center, Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, California, USA.

Periodic leg movements during sleep (PLMS) is a high prevalent sleep disorder of unknown etiology. The disease is pharmacologically treated with dopaminergic agonists (i.e.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!