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A loss-of-function AGTR1 variant in a critically-ill infant with renal tubular dysgenesis: case presentation and literature review.
BMC Nephrol
April 2024
Laboratory of Genomic Medicine, Sidra Medicine, P.O. Box 26999, Doha, Qatar.
Background: Renal tubular dysgenesis (RTD) is a severe disorder with poor prognosis significantly impacting the proximal tubules of the kidney while maintaining an anatomically normal gross structure. The genetic origin of RTD, involving variants in the ACE, REN, AGT, and AGTR1 genes, affects various enzymes or receptors within the Renin angiotensin system (RAS). This condition manifests prenatally with oligohydramninos and postnatally with persistent anuria, severe refractory hypotension, and defects in skull ossification.
View Article and Find Full Text PDFAneurysm Associated with Vascular Wall Degeneration in Bearded Dragons ().
Vet Pathol
May 2024
Northwest ZooPath, Monroe, WA.
This study describes the clinical, gross, and histologic findings in 17 cases of aneurysms in bearded dragons (). The clinical presentation ranged from incidental to sudden and unexpected death. The affected vasculature was predominantly arterial; however, based on the topographical locations of the lesions, gross structure, and drainage, some veins were likely involved.
View Article and Find Full Text PDFRegulation of cerebellar network development by granule cells and their molecules.
Front Mol Neurosci
July 2023
Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.
Article Synopsis
- The cerebellum plays a key role in motor coordination, learning, cognition, and emotion, shaped by organized structures and neuronal networks that develop over time.
- Cerebellar granule cells (GCs) are the most abundant neurons in the brain, generated from precursor cells and undergoing various developmental processes that also influence the cerebellum's growth and structure.
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Unpaired virtual histological staining using prior-guided generative adversarial networks.
Comput Med Imaging Graph
April 2023
The Third People's Hospital of Shenzhen, Buji Buran Road 29, Shenzhen, 518112, Guangdong, China. Electronic address:
Fibrosis is an inevitable stage in the development of chronic liver disease and has an irreplaceable role in characterizing the degree of progression of chronic liver disease. Histopathological diagnosis is the gold standard for the interpretation of fibrosis parameters. Conventional hematoxylin-eosin (H&E) staining can only reflect the gross structure of the tissue and the distribution of hepatocytes, while Masson trichrome can highlight specific types of collagen fiber structure, thus providing the necessary structural information for fibrosis scoring.
View Article and Find Full Text PDFOntogeny of a tessellated surface: Carapace growth of the longhorn cowfish Lactoria cornuta.
J Anat
September 2022
Comparative Zoology, Institute of Biology, Humboldt University of Berlin, Berlin, Germany.
Biological armors derive their mechanical integrity in part from their geometric architectures, often involving tessellations: individual structural elements tiled together to form surface shells. The carapace of boxfish, for example, is composed of mineralized polygonal plates, called scutes, arranged in a complex geometric pattern and nearly completely encasing the body. In contrast to artificial armors, the boxfish exoskeleton grows with the fish; the relationship between the tessellation and the gross structure of the armor is therefore critical to sustained protection throughout growth.
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