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Obeticholic acid improves hepatic bile acid excretion in patients with primary biliary cholangitis.
J Hepatol
January 2021
Department of Hepatology & Gastroenterology, Aarhus University Hospital, Aarhus, Denmark; Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark. Electronic address:
Background & Aims: Obeticholic acid (OCA) is an agonist of the nuclear bile acid receptor farnesoid X receptor, which regulates hepatic bile acid metabolism. We tested whether OCA treatment would influence hepatic transport of conjugated bile acids in patients with primary biliary cholangitis (PBC) who responded inadequately to treatment with ursodeoxycholic acid (UDCA).
Methods: Eight UDCA-treated patients with PBC with alkaline phosphatase ≥1.
Early versus delayed, provisional eptifibatide in acute coronary syndromes.
N Engl J Med
May 2009
TIMI (Thrombolysis in Myocardial Infarction) Study Group, Brigham and Women's Hospital, Boston, MA 02115, USA.
Background: Glycoprotein IIb/IIIa inhibitors are indicated in patients with acute coronary syndromes who are undergoing an invasive procedure. The optimal timing of the initiation of such therapy is unknown.
Methods: We compared a strategy of early, routine administration of eptifibatide with delayed, provisional administration in 9492 patients who had acute coronary syndromes without ST-segment elevation and who were assigned to an invasive strategy.
Commonly used eponyms in anesthesia.
J Clin Anesth
February 2009
Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA.
Names with eponym status in present-day anesthesia include Apgar, Bier, Bovie, Esmarch, Fick, Foley, Ganz, Hofmann, Huber, Joule, Luer, Macintosh, Magill, Mallampati, Miller, Ovassapian, Pascal, Ringer, Seldinger, Sellick, Swan, Trendelenburg, Tuohy, Valsalva, and Yankauer. A discussion of the people behind the eponyms, which may make these commonly used terms more interesting and provides a sense of the history of the specialty of anesthesia, is presented.
View Article and Find Full Text PDFCharacterization of chlorhexidine-releasing, fast-setting, brushite bone cements.
Acta Biomater
July 2008
Division of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, London, UK.
The effect of antibacterial chlorhexidine diacetate powder (CHX) on the setting kinetics of a brushite-forming beta-tricalcium phosphate/monocalcium phosphate monohydrate (beta-TCP/MCPM) cement was monitored using attenuated total reflection Fourier transform infrared spectroscopy. The final composition of the set cement with up to 12 wt.% CHX content before and after submersion in water for 24h, the kinetics of chlorhexidine release and the total sample mass change in water over four weeks was monitored using Raman mapping, UV spectroscopy and gravimetry, respectively.
View Article and Find Full Text PDFThree-dimensional color Doppler echocardiography for assessing shunt volume in atrial septal defects.
J Am Soc Echocardiogr
November 2004
Universitätsklinikum Hamburg-Eppendorf, Medizinische Klinik III, Hamburg, Germany.
Background Three-dimensional color Doppler echocardiography has been used to assess cardiac blood flow in experimental settings. We tested whether this technique can be applied to assess transatrial shunt flow in patients with atrial septal defect in a clinical setting. Methods In 46 consecutive patients with atrial septal defects, shunt flow was assessed during cardiac catheterization using the Fick method and by conventional 2-D quantitative transesophageal Doppler echocardiography.
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