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Idiopathic Intracranial Hypertension Is Associated with Recurrent CSF Leak and Reoperation for Spontaneous Temporal Encephalocele.
J Neurol Surg B Skull Base
October 2024
Department of Neurosurgery, Penn Medicine, Philadelphia, Pennsylvania, United States.
Spontaneous temporal encephaloceles (STEs) are increasingly recognized as sequelae of idiopathic intracranial hypertension (IIH), which in turn may further complicate their management. We endeavored to review the University of Pennsylvania institutional experience on operative management of STEs, with a focus on factors which may influence surgical outcomes, particularly IIH. Retrospective chart review over 9 years from 2013 to 2022.
View Article and Find Full Text PDFDizziness and Imbalance Across the Lifespan: Findings of a Pediatric and Adult Vestibular Clinic.
Otolaryngol Head Neck Surg
January 2025
Department of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Article Synopsis
- The study aimed to assess diagnostic trends in dizziness and imbalance in both pediatric and adult patients receiving multidisciplinary evaluations at a hospital from 2017 to 2020.
- A total of 1,934 patients, predominantly females, were reviewed, revealing that most were assigned a pathologic diagnosis, with central causes of dizziness more common in younger patients and peripheral disorders like BPPV and Meniere's disease more prevalent in older patients.
- The findings highlight the variability of vestibular disorders across different age groups, with conditions such as vestibular migraine being frequent in younger patients and an increase in peripheral vestibular disorders as patients age.
Patterns of Teprotumumab-Induced Hearing Dysfunction: A Systematic Review.
Otolaryngol Head Neck Surg
August 2024
Department of Otorhinolaryngology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Article Synopsis
- Study Purpose
- : The research aimed to analyze the relationship between the monoclonal antibody teprotumumab and hearing loss, reviewing existing evidence about its ototoxic effects.
- Data Review Process
- : A systematic review included 7 studies focusing on 109 patients who received teprotumumab, while excluding non-relevant articles and those lacking comprehensive audiometric data.
- Findings and Conclusion
- : Ototoxicity was identified in 41% of patients, mainly affecting higher frequency hearing. Enhanced screening for hearing issues is suggested, but the exact occurrence rate is still unclear, highlighting the need for further research.
Current Indications for Surgical Intervention With Lateral Skull Base Osteomyelitis.
Laryngoscope
January 2025
Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, U.S.A.
Toward a Diagnostic Imaging Algorithm for Undifferentiated Pulsatile Tinnitus.
Otol Neurotol
September 2024
Department of Otorhinolaryngology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Objective: Decisions around the diagnostic evaluation for pulsatile tinnitus (PT) remain challenging. We describe the usage patterns and diagnostic accuracy of imaging modalities and propose an evidence-based diagnostic approach for undifferentiated PT.
Study Design: Retrospective.
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