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Small-Angle and Quasi-Elastic Neutron Scattering from Polydisperse Oligolamellar Vesicles Containing Glycolipids.
J Phys Chem Lett
January 2025
Soft Matter Biophysics, Institute for Condensed Matter Physics, TU Darmstadt, Hochschulstraße 8, 64289 Darmstadt, Germany.
Glycolipids are known to stabilize biomembrane multilayers through preferential sugar-sugar interactions that act as weak transient membrane cross-links. Here, we use small-angle and quasi-elastic neutron scattering on oligolamellar phospholipid vesicles containing defined glycolipid fractions in order to elucidate the influence of glycolipids on membrane mechanics and dynamics. Small-angle neutron scattering (SANS) reveals that the oligolamellar vesicles (OLVs) obtained by extrusion are polydisperse with regard to the number of lamellae, , which renders the interpretation of the quasi-elastic neutron spin echo (NSE) data nontrivial.
View Article and Find Full Text PDFAn experimental study on the synergic damage of chemical solutions and stress to coal.
Sci Rep
January 2025
CSIRO Mineral Resources, Brisbane, QLD, 4069, Australia.
This paper investigates the impact of treatment with chemical solutions of varying pH values on the micro-macroscopic damage in coal samples under load, employing a combination of Small Angle X-ray Scattering (SAXS) experiments and uniaxial compression tests. The experimental results show that soaking coal samples in NaOH, HCl, and distilled water for 7 days leads to reductions in uniaxial compressive strength by 39.19%, 47.
View Article and Find Full Text PDFA composite hydrogel of porous gold nanorods and gelatin: Nanoscale structure and rheomechanical properties.
J Chem Phys
January 2025
Soft Matter and Nanomaterials Laboratory, Department of Physics, Indian Institute of Technology Bombay, Mumbai 400076, India.
Article Synopsis
- Incorporating nanomaterials into hydrogels allows for the creation of customizable materials with adjustable properties based on their nanoscale structures.
- This study explores the relationship between the structural arrangement and properties of a composite hydrogel made from thermoresponsive polymer, gelatin, and antimicrobial light-responsive gold nanorods (PAuNRs).
- Findings indicate that the addition of PAuNRs leads to a softer hydrogel with reduced elasticity, which can be tailored for specific biomedical applications like tissue engineering and drug delivery.
Spontaneous formation of small and ultrasmall unilamellar vesicles in mixtures of drug surfactant and phospholipid: Effect of chemical structure of phospholipid tails on vesicle size.
J Colloid Interface Sci
April 2025
Department of Medicinal Chemistry, Uppsala University, P.O. Box 547, 751 23, Uppsala, Sweden. Electronic address:
We have investigated the effect of length and chemical structure of phospholipid tails on the spontaneous formation of unilamellar liposomal vesicles in binary solute mixtures of cationic drug surfactant and zwitterionic phosphatidylcholine phospholipids. Binary drug surfactant-phospholipid mixtures with four different phospholipids with identical headgroups (two saturated phospholipids 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC, 14:0) and 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine (DPPC, 16:0), and two unsaturated lipids 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC, 18:1) and 1,2-Dierucoyl-sn-Glycero-3-Phosphatidylcholine (DEPC, 22:1)) combined with two different tricyclic antidepressant drugs (amitriptyline hydrochloride (AMT) and doxepin hydrochloride (DXP)) have been investigated with small-angle neutron scattering (SANS) and cryo-transmission electron microscopy (cryo-TEM). We observe a conspicuous impact of phospholipid tail structure on both micelle-to-vesicle transition point and vesicle size.
View Article and Find Full Text PDFThe distinctive mechanical and structural signatures of residual force enhancement in myofibers.
Proc Natl Acad Sci U S A
December 2024
Institute of Physiology II, University Hospital Muenster, University of Muenster, Muenster 48149, Germany.
In muscle, titin proteins connect myofilaments together and are thought to be critical for contraction, especially during residual force enhancement (RFE) when steady-state force is elevated after an active stretch. We investigated titin's function during contraction using small-angle X-ray diffraction to track structural changes before and after 50% titin cleavage and in the RFE-deficient, titin mutant. We report that the RFE state is structurally distinct from pure isometric contractions, with increased thick filament strain and decreased lattice spacing, most likely caused by elevated titin-based forces.
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