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Failure of intravenous flumazenil to antagonize alfaxalone anesthesia in cats.
J Feline Med Surg
March 2025
Zoetis Canada, Kirkland, QC, Canada.
ObjectivesThe aim of the present study was to assess the gamma-aminobutyric acid type A (GABA) receptor antagonist flumazenil and its effect on the anesthetic activity of the GABA receptor agonist alfaxalone when administered intravenously in cats.MethodsA prospective, randomized, blinded, two-period two-treatment crossover study was conducted. Eight (six male, two female) healthy adult neutered cats, 4.
View Article and Find Full Text PDFEfficacy of triplet antiemetic prophylaxis against chemotherapy-induced nausea and vomiting in patients with soft tissue sarcomas receiving consecutive-day doxorubicin and ifosfamide therapy.
Support Care Cancer
March 2025
Department of Pharmacy, Gifu University Hospital, 1-1 Yanagido, Gifu, Gifu, 501-1194, Japan.
Background: Doxorubicin and ifosfamide (AI) therapy for soft tissue sarcomas (STS) is given as a 5-day continuous-dose chemotherapy regimen, and classified as carrying high emetic risk. The purpose of this study was to evaluate the efficacy of triplet antiemetic prophylaxis, consisting of a 5-HT receptor antagonist, dexamethasone (DEX), and an NK receptor antagonist, against chemotherapy-induced nausea and vomiting (CINV) induced by AI therapy, and to determine the prophylactic antiemetic effect of the addition of olanzapine (OLZ) to this triplet antiemetic prophylaxis in cases of poor antiemesis.
Patients And Methods: Patients who received AI therapy for STS between October 2011 and October 2022 were included in this retrospective study.
Pharmaceutical Automated Reporting: An opioid stewardship tool.
J Opioid Manag
March 2025
Stewardship and Clinical Appropriateness, Saskatchewan Health Authority, Regina, Sas-katchewan, Canada. ORCID: https://orcid.org/0009-0005-2332-3923.
Objective: To develop and implement a customized clinical decision support system (CDSS) in an under-resourced health region aimed at promoting appropriate and safe opioid prescribing.
Design: The Pharmaceutical Automated Reporting (PAR) tool integrates inpatient prescription data from BDM Pharmacy (version 10) and categorizes patient information using predefined logic. It operates with Python (version 3.
Prevalence of Patients Admitted to Intensive Care After Administration of Chlordiazepoxide in the Emergency Room.
Basic Clin Pharmacol Toxicol
April 2025
Department of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark.
Chlordiazepoxide is effective in treating alcohol withdrawal syndrome, but it poses a risk of long-term sedation. The prevalence of this side effect and its risk factors remain uncertain. This retrospective cross-sectional study aimed to estimate both using data from Aarhus University Hospital's BI portal.
View Article and Find Full Text PDFIntroduction: The appropriate use of benzodiazepines for sedation during prolonged therapeutic endoscopy has not yet been established. This retrospective observational study compared the safety and efficacy of diazepam (DZP) and midazolam (MDZ) under moderate sedation during gastric endoscopic submucosal dissection (ESD).
Methods: We studied 554 patients who underwent gastric ESD under sedation with DZP or MDZ combined with pentazocine.
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