The present open study intended to show the prophylactic value of venlafaxine (serotonin and noradrenalin reuptake inhibitor) in 42 patients with migraine with or without aura during four months, from May to September 1997. The average age was 32.5 years and average crisis was 3.8 per month. Consistent side-effects included loss of weight, nausea and vomit. The efficacy of drug occurred in 37 patients (88.07%) with doses of 18.75 to 37.5 mg/day. We conclude that venlafaxine is an effective drug in prophylaxis of migraine patients.
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