AI Article Synopsis
- The number of calbindin D-28k and parvalbumin positive neurons in the inferior colliculus of mice increased following sound stimulation.
- New calbindin positive neurons were particularly noted in the deep layers of the external cortex, and more specifically in the dorsal cortex and commissural nucleus.
- An increase in parvalbumin positive neurons was found in several areas including the external cortex and dorsal cortex, indicating that these proteins may help protect against overstimulation and support heightened auditory activity, especially after noise-induced hearing loss.
Article Abstract
The numerical density of calbindin D-28k and parvalbumin immunopositive neurons in the inferior colliculus (IC) in mice was increased after sound stimulation. An increased number of calbindin positive neurons was found in the deep layers of the external cortex (EC) and particularly in the dorsal cortex (DC) and commissural nucleus (NCO). An increase of parvalbumin positive neurons was found in the EC, central nucleus (ICC) and DC, but not in the NCO. The increased immunoreactivity related to sound exposure suggests the appearance of neurons which express these proteins after sound stimulation. The up-regulation of calcium-binding proteins in these neurons may be due to their protective role against overstimulation, their response to a higher auditory metabolic activity, or increasing effect of excitatory inputs after noise-induced hearing loss.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0304-3940(98)00911-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hearing in categories and speech perception at the "cocktail party".
PLoS One
January 2025
School of Communication Sciences & Disorders, University of Memphis, Memphis, Tennessee, United States of America.
We aimed to test whether hearing speech in phonetic categories (as opposed to a continuous/gradient fashion) affords benefits to "cocktail party" speech perception. We measured speech perception performance (recognition, localization, and source monitoring) in a simulated 3D cocktail party environment. We manipulated task difficulty by varying the number of additional maskers presented at other spatial locations in the horizontal soundfield (1-4 talkers) and via forward vs.
View Article and Find Full Text PDFThe multifaceted role of the inferior colliculus in sensory prediction, reward processing, and decision-making.
Elife
January 2025
Department of Anesthesia, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
The inferior colliculus (IC) has traditionally been regarded as an important relay in the auditory pathway, primarily involved in relaying auditory information from the brainstem to the thalamus. However, this study uncovers the multifaceted role of the IC in bridging auditory processing, sensory prediction, and reward prediction. Through extracellular recordings in monkeys engaged in a sound duration-based deviation detection task, we observed a 'climbing effect' in neuronal firing rates, indicative of an enhanced response over sound sequences linked to sensory prediction rather than reward anticipation.
View Article and Find Full Text PDFResponse to "Comment on 'similar susceptibility to temporary hearing threshold shifts despite different audiograms in harbor porpoises and harbor seals' " [J. Acoust. Soc. Am. 157, 538-541 (2025)].
J Acoust Soc Am
January 2025
SEAMARCO, Julianalaan 46, 3843 CC Harderwijk, the Netherlands.
In their Comment, Tougaard et al. [(2025). J.
View Article and Find Full Text PDFBeta oscillations predict the envelope sharpness in a rhythmic beat sequence.
Sci Rep
January 2025
RITMO Centre for Interdisciplinary Studies in Rhythm, Time and Motion, University of Oslo, Forskningsveien 3A, Oslo, 0373, Norway.
Periodic sensory inputs entrain oscillatory brain activity, reflecting a neural mechanism that might be fundamental to temporal prediction and perception. Most environmental rhythms and patterns in human behavior, such as walking, dancing, and speech do not, however, display strict isochrony but are instead quasi-periodic. Research has shown that neural tracking of speech is driven by modulations of the amplitude envelope, especially via sharp acoustic edges, which serve as prominent temporal landmarks.
View Article and Find Full Text PDFaPD-L1-facilitated theranostic and tumor microenvironment remodeling of pancreatic cancer via docetaxel-loaded phase-transformation nanoparticles triggered by low-intensity pulsed ultrasound.
J Nanobiotechnology
January 2025
Department of Ultrasound, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, China.
Early diagnosis of pancreatic ductal adenocarcinoma (PDAC) is challenging because of its depth, which often leads to misdiagnosis during ultrasound examinations. The unique PDAC tumor microenvironment (TME) is characterized by significant fibrous tissue growth, and high interstitial pressure hinders drug penetration into tumors. Additionally, hypoxia and immune suppression within the tumor contribute to poor responses to radiotherapy and chemotherapy, ultimately leading to an unfavorable prognosis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!