AI Article Synopsis
- Previous studies on Nordic and Italian groups suggested that chromosomal aberrations (CAS) might predict cancer, while sister chromatid exchanges (SCES) did not.
- A new pooled analysis will combine data from 5,271 subjects for a more comprehensive evaluation of cytogenetic biomarkers.
- The study will also consider factors like gender, age, time since testing, occupational exposures, and smoking to determine their influence on cancer predictability using Poisson regression models.
Article Abstract
It has not previously been clear whether cytogenetic biomarkers in healthy subjects will predict cancer. Earlier analyses of a Nordic and an Italian cohort indicated predictivity for chromosomal aberrations (CAS) but not for sister chromatid exchanges (SCES). A pooled analysis of the updated cohorts, forming a joint study base of 5271 subjects, will now be performed, allowing a more solid evaluation. The importance of potential effect modifiers, such as gender, age at testing, and time since testing, will be evaluated using Poisson regression models. Two other potential effect modifiers, occupational exposures and smoking, will be assessed in a case-referent study within the study base.
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| http://dx.doi.org/10.1007/978-3-642-46870-4_10 | DOI Listing |
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