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Digital papillary adenocarcinoma: A case report of a rare malignant tumour with recommendations on management and follow-up.
Int J Surg Case Rep
January 2025
Department of Plastic and Reconstructive Surgery, University Hospital North Durham, Durham DH1 5TW, United Kingdom. Electronic address:
Introduction: Digital papillary adenocarcinoma (DPAC) is a rare malignant tumour of the sweat glands, usually in the digits. It has a high rate of recurrence and metastasis, yet there's a lack of guidelines for its diagnosis and management. Therefore, this report aims to evaluate procedures that provide the best outcomes, which will help create a consensus for its management.
View Article and Find Full Text PDFUtility of systemic staging in breast cancer patients with a positive sentinel lymph node biopsy.
Ir J Med Sci
January 2025
Department of Breast Surgery, St. Vincent's University Hospital, Dublin 4, D04 T6F4, Ireland.
Background: CT thorax, abdomen and pelvis (CT-TAP) remains the standard in the identification of metastatic disease in patients with newly diagnosed breast cancer. In patients with proven micro and macro axillary nodal metastasis, the optimal radiological technique remains controversial. A consensus on which patients with axillary nodal disease should receive radiological staging for distant disease and how this should be performed is not currently available.
View Article and Find Full Text PDFMore micrometastases, more recurrence? The role of qPCR of PSA mRNA in lymph nodes during prostatectomy.
World J Urol
January 2025
Department of Urology, Urooncology, Robot-assisted and Focal Therapy, University Hospital Magdeburg, Otto-von Guericke University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany.
Background And Objectives: Radical prostatectomy is a standard treatment for prostate cancer, yet about 30% of patients experience rising biochemical markers within a decade post-surgery. Pelvic lymph node sampling during prostatectomy assesses potential lymph node metastases, but standard histological assessments, which typically examine only 2-3 tissue sections, often miss occult metastases. This study assesses the effectiveness of qPCR in detecting PSA coding KLK3 mRNA for identifying lymph node metastases post-prostatectomy and explores the correlation between PSA-mRNA and biochemical recurrence.
View Article and Find Full Text PDFSignificance of sentinel lymph node biopsy in low- and intermediate- risk endometrial cancer: a study at tertiary care centre, India.
Obstet Gynecol Sci
December 2024
Department of NAME, Chairman-Max Institute of Cancer Care, Pan Max, Delhi, India.
Objective: To evaluate the incidence of sentinel lymph node (SLN) metastasis observed in patients with presumed low- and intermediate-risk endometrial cancer (EC) and change in stage and adjuvant therapy resulting from SLN analysis. Secondary objectives include assessing the rates of detection of SLN using indocyanine green (ICG) dye and complication rates.
Methods: Between March 2017 and December 2023, 210 patients were included in the study.
In vivo self-assembled bispecific fluorescence probe for early detection of bladder cancer and metastasis.
Sci Bull (Beijing)
October 2024
NHC Key Laboratory of Molecular Probe and Targeted Theranostics, Heilongjiang Key Laboratory of Scientific Research in Urology, Harbin Medical University, Harbin 150001, China. Electronic address:
Article Synopsis
- * bsProbe shows significantly improved tumor accumulation—about six times more than traditional probes—enhancing detection capabilities for small tumors and providing a clearer distinction between malignant and benign tissues.
- * With a specificity of 90.48% and sensitivity of 92.22% based on analysis of 195 bladder cancer specimens, the bsProbe could improve early diagnosis and may aid in imaging-guided surgeries for tumors that are not visible.
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