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Suspected Malignant Hyperthermia in a Brain-Dead Donor During Anesthesia for Organ Procurement Surgery: A Case Report.
Transplant Proc
October 2023
Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
We report an unusual case of highly suspected malignant hyperthermia after inducing anesthesia in a brain-dead 18-year-old male patient undergoing organ procurement surgery. The patient was administered desflurane (3 vol%) and rocuronium bromide (50 mg) to induce and maintain general anesthesia. He experienced hypercapnia and tachycardia within 5 minutes of anesthesia induction; however, his body temperature rapidly rose only after 15 minutes.
View Article and Find Full Text PDFHepatotoxic and neuroendocrine effects in physicians occupationally exposed to most modern halogenated anesthetics and nitrous oxide.
Environ Toxicol Pharmacol
January 2021
Department of Anesthesiology, Medical School, São Paulo State University - UNESP, Botucatu, Brazil. Electronic address:
The lack of data on hepatic and hormonal markers for occupational exposure to most modern halogenated anesthetics has stimulated our research, which assessed liver enzymes, high-sensitivity C-reactive protein (hs-CRP) and neuroendocrine response. The study investigated 106 physicians who were categorized in an exposed group (primarily exposed to isoflurane and sevoflurane and less to desflurane and nitrous oxide) as well as as a control group. Anesthetic air monitoring was performed, and biological samples were analyzed for the most important liver enzymes, hs-CRP, adrenocorticotrophic hormone, cortisol and prolactin.
View Article and Find Full Text PDFFluorine-Containing Inhalation Anesthetics: Chemistry, Properties and Pharmacology.
Curr Med Chem
December 2020
School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi Road, Wuhan 430070, China.
Article Synopsis
- This review summarizes research on the synthesis, chemistry, and pharmacology of fluorinated inhalation anesthetics, highlighting their historical development and increasing use of fluorine and ether structures.
- Halothane, an older anesthetic, caused severe liver toxicity, leading to enflurane's introduction in the 1970s, followed by isoflurane in the 1980s, which offered some improvements.
- Despite advancements with desflurane and sevoflurane in the 1990s providing lower toxicity and better anesthetic properties, developing even better options remains difficult due to challenges in predicting anesthetic activity from molecular structures and various synthetic hurdles.
A prospective study of the incidence of drug-induced liver injury by the modern volatile anaesthetics sevoflurane and desflurane.
Aliment Pharmacol Ther
April 2019
Melbourne Medical School, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia.
Background: Volatile anaesthetics are known to cause drug-induced liver injury, a hepatotoxic reaction characterised by antibodies to trifluoroacetylated lipid and protein adducts and cytochrome p450 2E1. The incidence of volatile anaesthetic drug-induced liver injury from older agents has been described, but modern agents have not been prospectively studied.
Aim: To determine prospectively the incidence of volatile anaesthetic drug-induced liver injury from sevoflurane and desflurane.
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