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High dose nanocrystalline solid dispersion powder of voriconazole for inhalation.
Int J Pharm
June 2022
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, SAS Nagar, Mohali, Punjab 160062, India. Electronic address:
Article Synopsis
- - The research focused on delivering high doses of voriconazole (VRC) to the lungs using a dry powder for inhalation (DPI) method, exploring the potential of drug nanocrystals to bypass lung clearance mechanisms because of their small size and quick dissolution.
- - A novel spray drying technique was utilized to create nanocrystalline solid dispersion (NCSD) of VRC, using mannitol (as a crystallization inducer) and soya lecithin (as a stabilizer), and the formulation's properties were extensively analyzed.
- - The study found that the NCSD formulation (VRC-N) had better dissolution and lung absorption compared to a microcrystalline version (VRC-M), resulting in higher drug
Spinal Tissue Loading Created by Different Methods of Spinal Manipulative Therapy Application.
Spine (Phila Pa 1976)
May 2017
Department of Physical Therapy, University of Alberta, Edmonton, AB, Canada.
Study Design: Comparative study using robotic replication of spinal manipulative therapy (SMT) vertebral kinematics together with serial dissection.
Objective: The aim of this study was to quantify loads created in cadaveric spinal tissues arising from three different forms of SMT application.
Summary Of Background Data: There exist many distinct methods by which to apply SMT.
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