AI Article Synopsis
- The nervous system integrates pain signals through different levels: peripheral (outside the brain and spinal cord), spinal (in the spinal cord), and supraspinal (in the brain).
- Different neurotransmitters and modulators either promote or inhibit the sensation of pain during processing.
- Chronic pain can lead to changes in how these pain pathways function and are structured, presenting new opportunities for targeted treatments.
Article Abstract
Integration of nociceptive signaling comprises peripheral, spinal, and supraspinal sites of the nervous system. Various excitatory or inhibitory neurotransmitter and--modulator systems participate in pain processing and modulation. Chronic pain states are associated with functional and structural alterations of nociceptive pathways. The numerous dynamic changes in the pharmacologically distinct systems offer novel targets for selective pharmacotherapy.
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| http://dx.doi.org/10.1007/s003930050224 | DOI Listing |
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