Prepulse inhibition (PPI) and habituation of the startle response are operational measures of sensorimotor gating and information processing. Changes in the normal inhibition and habituation of the startle response may provide trait markers for illnesses such as schizophrenia that have altered neurotransmitter control of the neural circuitry that modulates these measures. The stability of PPI and habituation was assessed in 10 normal male subjects. Prepulse inhibition was found to be most stable in the more intense prepulse conditions, and habituation was most stable in the early portion of the test session. These data support the hypothesis that PPI and habituation are relatively stable neurobiological markers.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0006-3223(98)00294-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of Metabolic Dysfunction-Associated Steatohepatitis in Alertness, Associative Learning, and Astrocyte Density.
Brain Behav
January 2025
INEUROPA, Instituto de Neurociencias del Principado de Asturias, Oviedo, Spain.
Purpose: Metabolic dysfunction-associated steatohepatitis (MASH) is a prevalent disease caused by high fat and high cholesterol intake, which leads to systemic deterioration. The aim of this research is to conduct a psychobiological exploration of MASH in adult male rats.
Methods: Subjects who were administered a high-fat and high-cholesterol diet for 14 weeks.
Clozapine and rapamycin reverse behavioral abnormalities in an animal model of autoimmune schizophrenia.
Neuropharmacology
December 2024
State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China; Neuroscience Center, Chinese Academy of Medical Sciences, Beijing, China. Electronic address:
Objective: Autoantibody-associated psychosis represents a distinct disease subgroup of patients with schizophrenia with a suspected autoimmune origin. Although preliminary studies have suggested adjunctive drug treatment strategies targeting the immune system, further validation of these findings is warranted. Autoantibodies against SFT2D2 have been identified in patients with schizophrenia.
View Article and Find Full Text PDFThe role of deep layer superior colliculus neurons in prepulse inhibition and the impact of spatial separation in male rats.
Neuroscience
December 2024
School of Psychological and Cognitive Sciences, Peking University, Beijing 100080, China.
Prepulse inhibition (PPI) refers to the phenomenon in which a weak sensory stimulus before a strong one significantly reduces the startle reflex caused by the strong stimulus. Perceptual spatial separation, a phenomenon where auditory cues from the prepulse and background noise are distinguished in space, has been shown to enhance PPI. This study aims to investigate the neural modulation mechanisms of PPI by the spatial separation between the prepulse stimulus and background noise, particularly in the deep superior colliculus (deepSC).
View Article and Find Full Text PDFThe effect of ovariectomy, 17β-estradiol treatment, and progesterone treatment on dopaminergic regulation of prepulse inhibition in adult and adolescent female mice.
Horm Behav
December 2024
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia.
The aim of the present study was to investigate the role of ovarian hormones on dopaminergic regulation of prepulse inhibition (PPI), a measure of sensorimotor gating deficient in schizophrenia and other psychiatric illnesses. Either in adulthood (11 weeks of age) or adolescence (5 weeks of age), female mice underwent ovariectomy (OVX) and were implanted with 17β-estradiol, progesterone, or a combination of these hormones. All mice were tested in adulthood for the acute effect of the dopamine receptor agonist, apomorphine, on PPI.
View Article and Find Full Text PDFPyridoxine supplementation before puberty ameliorates MAM-induced cognitive and sensorimotor gating impairments.
Metab Brain Dis
December 2024
School of Medicine, Jiangsu University, Zhenjiang, Jiangsu Province, 212013, PR China.
Schizophrenia is a kind of neurodevelopmental mental disorder in which patients begin to experience changes early in their development, typically manifesting around or after puberty and has a fluctuating course. Environmental disturbances during adolescence may be a risk factor for schizophrenia-like deficits. As a better treatment option, preventive intervention prior to schizophrenia may be more beneficial than direct treatment.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!