The 4-oxospiro[benzopyran-2,4'-piperidine] ring system is contained within potent class III antiarrhythmic agents. We highlight how these agents can be chemically transformed into a new class of potent (< 1 nM) and selective (> 25-fold) alpha 1a-receptor subtype adrenergic antagonists.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0960-894x(98)00732-x | DOI Listing |
Publication Analysis
Top Keywords
4-oxospiro[benzopyran-24'-piperidines] selective
4
selective alpha
4
alpha 1a-adrenergic
4
1a-adrenergic receptor
4
receptor antagonists
4
antagonists 4-oxospiro[benzopyran-24'-piperidine]
4
4-oxospiro[benzopyran-24'-piperidine] ring
4
ring system
4
system contained
4
contained potent
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!