Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1103/physrevd.53.r3487 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Crystallographic analysis of the Escherichia coli tRNA seleno-modification enzyme in complex with tRNA.
Acta Crystallogr F Struct Biol Commun
February 2025
Graduate School of Life Science, Hokkaido University, Kita 10, Nishi 8, Kita-ku, Sapporo, Hokkaido 060-0810, Japan.
The bacterial enzyme tRNA 2-selenouridine synthase (SelU) catalyzes the conversion of 5-substituted 2-thiouridine (R5S2U) to 5-substituted 2-selenouridine (R5Se2U) at the wobble positions of several tRNAs. Seleno-modification potentially regulates translation efficiency in response to selenium availability. Notably, SelU uses the 2-geranylthiouridine (R5geS2U) intermediate for sulfur removal, and this geranylthiol (geS) is a unique leaving group among tRNA-maturation enzymes.
View Article and Find Full Text PDFBiosynthesis and Characterization of Silver Nanoparticles and Simvastatin Association in Titanium Biofilms.
Pharmaceuticals (Basel)
November 2024
Laboratório de Farmacologia de Antimicrobianos e Microbiologia, Faculdade de Ciências Farmacêuticas, Universidade Estadual de Campinas (UNICAMP), Campinas 13083-970, Brazil.
Introduction: Simvastatin is an antilipidemic drug that has already demonstrated antibacterial activities on oral and non-oral microorganisms. Silver nanoparticles also exhibit antimicrobial properties, particularly for coating implant surfaces. In this study, we evaluated the effects of combining simvastatin with silver nanoparticles on the formation and viability of biofilms consolidated on titanium discs.
View Article and Find Full Text PDFRaman Spectroscopic Analysis of Molecular Structure and Mechanical Properties of Hypophosphatasia Primary Tooth.
Molecules
December 2024
Department of Dental Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto 602-8566, Japan.
Mild hypophosphatasia (HPP) can be difficult to distinguish from other bone disorders in the absence of typical symptoms such as the premature loss of primary teeth. Therefore, this study aimed to analyze the crystallinity of hydroxyapatite (HAp) and the three-dimensional structure of collagen in HPP teeth at the molecular level and to search for new biomarkers of HPP. Raman spectroscopy was used to investigate the molecular structure, composition, and mechanical properties of primary teeth from healthy individuals and patients with HPP.
View Article and Find Full Text PDFCationic -Tricarbollide μ-10,11-H-10,11-H-7-MeN--7,8,9-CBH and Its Halogenated Derivatives: The Slow Iodination Process Occurring through Cationic Iodonium Tricarbollides.
Inorg Chem
January 2025
Institute of Inorganic Chemistry, Czech Academy of Sciences, CZ, 250 68 Husinec-Řež, Czech Republic.
A series of -tricarbollides based on 10,11-X-7-MeN--7,8,9-CBH (X = H, Cl, Br, I) and their protonated, i.e. cationic, counterparts, which have an extra H-bridge over the B10-B11 vector in the open pentagonal belt, were prepared.
View Article and Find Full Text PDFSCXRD, CSP-NMRX and microED in the quest for three elusive polymorphs of meloxicam.
IUCrJ
January 2025
Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, Lodz 90-363, Poland.
Crystal structure determination is a crucial aspect of almost every branch of the chemical sciences, bringing us closer to understanding crystallization, polymorphism, phase transitions, and the relationship between a structure and its physicochemical and functional properties. Unfortunately, many molecules notoriously crystallize as microcrystalline powders, providing a significant challenge in establishing their structures. In this work, we describe the crystal structure determination of three elusive polymorphs of the anti-inflammatory drug meloxicam (MLX) using three approaches, of which only one was successful for each crystal phase.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!