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Celastrol boosts fluconazole efficacy against vaginal candidiasis: in vitro and in vivo evidence.
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Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt.
Candida albicans is a commensal fungus that naturally inhabits the vagina. However, overgrowth of C. albicans can result in vulvovaginal candidiasis (VVC), one of the most prevalent fungal infections affecting women.
View Article and Find Full Text PDFExecutive dysfunction in Parkinson's disease: From neurochemistry to circuits, genetics and neuroimaging.
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Department of Rehabilitation, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China; Department of Neurology, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China; Department of Clinical Medical Research Center, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China. Electronic address:
Cognitive decline is one of the most significant non-motor symptoms of Parkinson's disease (PD), with executive dysfunction (EDF) being the most prominent characteristic of PD-associated cognitive deficits. Currently, lack of uniformity in the conceptualization and assessment scales for executive functions impedes the early and accurate diagnosis of executive dysfunction in PD. The neurobiological mechanisms of executive dysfunction in PD remain poorly understood.
View Article and Find Full Text PDFElafibranor, a dual PPARα and PPARδ agonist, reduces alcohol-associated liver disease: Lessons from a mouse model.
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Carmen Laboratory, INSERM Unit 1060-Lyon 1 University, Pierre Benite 69310, France.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent liver pathology in need of novel pharmacological treatments to complement lifestyle-based interventions. Nuclear receptor agonists have been under scrutiny as potential pharmacological targets and as of today, resmetirom, a thyroid hormone receptor b agonist, is the only approved agent. The dual PPAR α and δ agonist elafibranor has also undergone extensive clinical testing, which reached the phase III clinical trial but failed to demonstrate a beneficial effect on MASLD.
View Article and Find Full Text PDFThe integration and innovative practice of intelligent AI and local opera in college teaching.
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Xuzhou University of Technology, Xuzhou, China.
This paper explores the impacts of integrating AI into the teaching of Chinese Opera using a mixed-methods approach, examining performance, engagement, and psychological factors in students. A quasi-experimental design involving 199 participants over a one-year period was conducted, involving teaching with and without AI enhancement. Quantitative data, derived from standardized tests and analytics provided by AI platforms, were supported by qualitative data from interviews and observational studies.
View Article and Find Full Text PDFA methodological approach to assess the ropy character of stirred acid dairy gels based on the measure of adhesiveness.
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Department of Food Science, STELA Dairy Science and Technology Research Center, Institute of Nutrition and Functional Foods (INAF), Laval University, Québec City, QC, Canada G1V 0A6.
This work aims to evaluate the potential and limits of adhesiveness measurement using a texturometer to assess the ropiness of acid dairy gels for starter selection. Commercial yogurts of various formulations and textures were used to assess the ability of adhesiveness to detect ropiness and to compare performance of different probes. Chemically acidified gels using different concentrations of glucono-delta-lactone (GDL) were tested to determine the effect of pH on adhesiveness.
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